Your browser doesn't support javascript.
loading
Sulfasalazine ameliorates lipopolysaccharide-induced acute lung injury by inhibiting oxidative stress and nuclear factor-kappaB pathways.
Cheng, Hai-Peng; Bao, Xing-Wen; Luo, Yong-Yu; Li, Yang-Hang; Zhou, Yan; Hua, Qing-Zhong; Qiu, Yu-Jia; Liang, Xin-Yue; Huang, Yan-Hong; Liu, Wei; Tang, Si-Yuan; Feng, Dan-Dan; Li, Chen; Luo, Zi-Qiang.
Afiliación
  • Cheng HP; Department of Pathology, The Second Xiangya Hospital, Central South University, Changsha, Hunan, China.
  • Bao XW; Department of Physiology, Xiangya School of Medicine, Central South University, Changsha, Hunan, China.
  • Luo YY; Department of Physiology, Xiangya School of Medicine, Central South University, Changsha, Hunan, China.
  • Li YH; Department of Physiology, Xiangya School of Medicine, Central South University, Changsha, Hunan, China.
  • Zhou Y; Department of Physiology, Xiangya School of Medicine, Central South University, Changsha, Hunan, China.
  • Hua QZ; Xiangya Nursing School, Central South University, Changsha, Hunan, China.
  • Qiu YJ; Department of Physiology, Xiangya School of Medicine, Central South University, Changsha, Hunan, China.
  • Liang XY; Department of Physiology, Xiangya School of Medicine, Central South University, Changsha, Hunan, China.
  • Huang YH; Department of Physiology, Xiangya School of Medicine, Central South University, Changsha, Hunan, China.
  • Liu W; Xiangya Nursing School, Central South University, Changsha, Hunan, China.
  • Tang SY; Xiangya Nursing School, Central South University, Changsha, Hunan, China.
  • Feng DD; Department of Physiology, Xiangya School of Medicine, Central South University, Changsha, Hunan, China.
  • Li C; Department of Physiology, Changzhi Medical College, Changzhi, Shanxi, China. Electronic address: c.li@czmc.edu.cn.
  • Luo ZQ; Department of Physiology, Xiangya School of Medicine, Central South University, Changsha, Hunan, China; Hunan Key Laboratory of Organ Fibrosis, Central South University, Changsha, Hunan, China. Electronic address: luoziqiang@csu.edu.cn.
Int J Biochem Cell Biol ; 169: 106530, 2024 Apr.
Article en En | MEDLINE | ID: mdl-38246263
ABSTRACT
Acute lung injury/acute respiratory distress syndrome (ALI/ARDS) has a high mortality rate and incidence of complications. The pathophysiology of ALI/ARDS is still not fully understood. The lipopolysaccharide (LPS)-induced mouse model of ALI has been widely used to study human ALI/ARDS. Sulfasalazine (SASP) has antibacterial and anti-inflammatory effects and is used for treating inflammatory bowel and rheumatic diseases. However, the effect of SASP on LPS-induced ALI in mice has not yet been reported. Therefore, we aimed to investigate the effect of SASP on LPS-induced ALI in mice. Mice were intraperitoneally injected with SASP 2 h before or 4 h after LPS modeling. Pulmonary pathological damage was measured based on inflammatory factor expression (malondialdehyde and superoxide dismutase levels) in the lung tissue homogenate and alveolar lavage fluid. The production of inflammatory cytokines and occurrence of oxidative stress in the lungs induced by LPS were significantly mitigated after the prophylactic and long-term therapeutic administration of SASP, which ameliorated ALI caused by LPS. SASP reduced both the production of inflammatory cytokines and occurrence of oxidative stress in RAW264.7 cells, which respond to LPS. Moreover, its mechanism contributed to the suppression of NF-κB and nuclear translocation. In summary, SASP treatment ameliorates LPS-induced ALI by mediating anti-inflammatory and antioxidant effects, which may be attributed to the inhibition of NF-κB activation and promotion of antioxidant defenses. Thus, SASP may be a promising pharmacologic agent for ALI therapy.
Asunto(s)
Palabras clave
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Síndrome de Dificultad Respiratoria / Lesión Pulmonar Aguda Tipo de estudio: Prognostic_studies Límite: Animals / Humans Idioma: En Revista: Int J Biochem Cell Biol Asunto de la revista: BIOQUIMICA Año: 2024 Tipo del documento: Article País de afiliación: China Pais de publicación: Países Bajos
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Síndrome de Dificultad Respiratoria / Lesión Pulmonar Aguda Tipo de estudio: Prognostic_studies Límite: Animals / Humans Idioma: En Revista: Int J Biochem Cell Biol Asunto de la revista: BIOQUIMICA Año: 2024 Tipo del documento: Article País de afiliación: China Pais de publicación: Países Bajos