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Biochemical pancreatic ß-cell lineage reprogramming: Various cell fate shifts.
Wang, Yuqin; Liu, Zhuoqing; Li, Shengren; Su, Xuejuan; Lai, Keng Po; Li, Rong.
Afiliación
  • Wang Y; Key Laboratory of Environmental Pollution and Integrative Omics, Education Department of Guangxi Zhuang Autonomous Region, Guilin Medical University, 1 Zhiyuan Road, Lingui District, Guilin 541199, China.
  • Liu Z; School of Pharmacy, Guilin Medical University, Guilin, China.
  • Li S; Lingui Clinical College of Guilin Medical University, Guilin, China.
  • Su X; Lingui Clinical College of Guilin Medical University, Guilin, China.
  • Lai KP; Key Laboratory of Environmental Pollution and Integrative Omics, Education Department of Guangxi Zhuang Autonomous Region, Guilin Medical University, 1 Zhiyuan Road, Lingui District, Guilin 541199, China.
  • Li R; Key Laboratory of Environmental Pollution and Integrative Omics, Education Department of Guangxi Zhuang Autonomous Region, Guilin Medical University, 1 Zhiyuan Road, Lingui District, Guilin 541199, China. Electronic address: lirong1278@163.com.
Curr Res Transl Med ; 72(1): 103412, 2024 03.
Article en En | MEDLINE | ID: mdl-38246021
ABSTRACT
The incidence of pancreatic diseases has been continuously rising in recent years. Thus, research on pancreatic regeneration is becoming more popular. Chronic hyperglycemia is detrimental to pancreatic ß-cells, leading to impairment of insulin secretion which is the main hallmark of pancreatic diseases. Obtaining plenty of functional pancreatic ß-cells is the most crucial aspect when studying pancreatic biology and treating diabetes. According to the International Diabetes Federation, diabetes has become a global epidemic, with about 3 million people suffering from diabetes worldwide. Hyperglycemia can lead to many dangerous diseases, including amputation, blindness, neuropathy, stroke, and cardiovascular and kidney diseases. Insulin is widely used in the treatment of diabetes; however, innovative approaches are needed in the academic and preclinical stages. A new approach aims at synthesizing patient-specific functional pancreatic ß-cells. The present article focuses on how cells from different tissues can be transformed into pancreatic ß-cells.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Enfermedades Pancreáticas / Diabetes Mellitus / Hiperglucemia Límite: Humans Idioma: En Revista: Curr Res Transl Med Año: 2024 Tipo del documento: Article País de afiliación: China Pais de publicación: Francia
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Enfermedades Pancreáticas / Diabetes Mellitus / Hiperglucemia Límite: Humans Idioma: En Revista: Curr Res Transl Med Año: 2024 Tipo del documento: Article País de afiliación: China Pais de publicación: Francia