Your browser doesn't support javascript.
loading
Shifting patterns of dengue three years after Zika virus emergence in Brazil.
Pinotti, Francesco; Giovanetti, Marta; de Lima, Maricelia Maia; de Cerqueira, Erenilde Marques; Alcantara, Luiz C J; Gupta, Sunetra; Recker, Mario; Lourenço, José.
Afiliación
  • Pinotti F; Department of Biology, University of Oxford, Oxford, United Kingdom. francesco.pinotti@biology.ox.ac.uk.
  • Giovanetti M; Laboratório de Flavivírus, Instituto Oswaldo Cruz, Fundação Oswaldo Cruz, Rio de Janeiro, Brazil.
  • de Lima MM; Instituto Rene Rachou, Fundação Oswaldo Cruz, Belo Horizonte, Minas Gerais, Brazil.
  • de Cerqueira EM; Sciences and Technologies for Sustainable Development and One Health, University of Campus Bio-Medico di Roma, Rome, Italy.
  • Alcantara LCJ; Universidade Estadual de Feira de Santana, Feira de Santana, Bahia, Brazil.
  • Gupta S; Universidade Estadual de Feira de Santana, Feira de Santana, Bahia, Brazil.
  • Recker M; Laboratório de Flavivírus, Instituto Oswaldo Cruz, Fundação Oswaldo Cruz, Rio de Janeiro, Brazil.
  • Lourenço J; Instituto Rene Rachou, Fundação Oswaldo Cruz, Belo Horizonte, Minas Gerais, Brazil.
Nat Commun ; 15(1): 632, 2024 Jan 20.
Article en En | MEDLINE | ID: mdl-38245500
ABSTRACT
In 2015, the Zika virus (ZIKV) emerged in Brazil, leading to widespread outbreaks in Latin America. Following this, many countries in these regions reported a significant drop in the circulation of dengue virus (DENV), which resurged in 2018-2019. We examine age-specific incidence data to investigate changes in DENV epidemiology before and after the emergence of ZIKV. We observe that incidence of DENV was concentrated in younger individuals during resurgence compared to 2013-2015. This trend was more pronounced in Brazilian states that had experienced larger ZIKV outbreaks. Using a mathematical model, we show that ZIKV-induced cross-protection alone, often invoked to explain DENV decline across Latin America, cannot explain the observed age-shift without also assuming some form of disease enhancement. Our results suggest that a sudden accumulation of population-level immunity to ZIKV could suppress DENV and reduce the mean age of DENV incidence via both protective and disease-enhancing interactions.
Asunto(s)
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Dengue / Virus del Dengue / Virus Zika / Infección por el Virus Zika Límite: Humans País/Región como asunto: America do sul / Brasil Idioma: En Revista: Nat Commun Asunto de la revista: BIOLOGIA / CIENCIA Año: 2024 Tipo del documento: Article País de afiliación: Reino Unido Pais de publicación: Reino Unido
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Dengue / Virus del Dengue / Virus Zika / Infección por el Virus Zika Límite: Humans País/Región como asunto: America do sul / Brasil Idioma: En Revista: Nat Commun Asunto de la revista: BIOLOGIA / CIENCIA Año: 2024 Tipo del documento: Article País de afiliación: Reino Unido Pais de publicación: Reino Unido