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Brainstem processing of cough sensory inputs in chronic cough hypersensitivity.
Moe, Aung Aung Kywe; Singh, Nabita; Dimmock, Matthew; Cox, Katherine; McGarvey, Lorcan; Chung, Kian Fan; McGovern, Alice E; McMahon, Marcus; Richards, Amanda L; Farrell, Michael J; Mazzone, Stuart B.
Afiliación
  • Moe AAK; Department of Anatomy and Physiology, University of Melbourne, Parkville, VIC, Australia; Department of Medical Imaging and Radiation Sciences, Monash University, Clayton, VIC, Australia.
  • Singh N; Department of Medical Imaging and Radiation Sciences, Monash University, Clayton, VIC, Australia.
  • Dimmock M; Department of Medical Imaging and Radiation Sciences, Monash University, Clayton, VIC, Australia; School of Allied Health Professions, Keele University, Staffordshire, UK.
  • Cox K; Centre for Human Psychopharmacology, Swinburne University, Australia.
  • McGarvey L; Wellcome-Wolfson Institute for Experimental Medicine, School of Medicine, Dentistry and Biomedical Sciences, Queen's University Belfast, Belfast, UK.
  • Chung KF; Experimental Studies Unit, National Heart & Lung Institute, Imperial College London, UK; Department of Respiratory Medicine, Royal Brompton and Harefield Hospital, London, UK.
  • McGovern AE; Department of Anatomy and Physiology, University of Melbourne, Parkville, VIC, Australia.
  • McMahon M; Department of Respiratory and Sleep Medicine, Austin Hospital, Heidelberg, Australia.
  • Richards AL; Department of Otolaryngology, The Royal Melbourne Hospital, Parkville, VIC, Australia.
  • Farrell MJ; Department of Medical Imaging and Radiation Sciences, Monash University, Clayton, VIC, Australia; Monash Biomedical Imaging, Monash University, Clayton, VIC, Australia.
  • Mazzone SB; Department of Anatomy and Physiology, University of Melbourne, Parkville, VIC, Australia. Electronic address: stuart.mazzone@unimelb.edu.au.
EBioMedicine ; 100: 104976, 2024 Feb.
Article en En | MEDLINE | ID: mdl-38244293
ABSTRACT

BACKGROUND:

Chronic cough is a prevalent and difficult to treat condition often accompanied by cough hypersensitivity, characterised by cough triggered from exposure to low level sensory stimuli. The mechanisms underlying cough hypersensitivity may involve alterations in airway sensory nerve responsivity to tussive stimuli which would be accompanied by alterations in stimulus-induced brainstem activation, measurable with functional magnetic resonance imaging (fMRI).

METHODS:

We investigated brainstem responses during inhalation of capsaicin and adenosine triphosphate (ATP) in 29 participants with chronic cough and 29 age- and sex-matched controls. Psychophysical testing was performed to evaluate individual sensitivities to inhaled stimuli and fMRI was used to compare neural activation in participants with cough and control participants while inhaling stimulus concentrations that evoked equivalent levels of urge-to-cough sensation.

FINDINGS:

Participants with chronic cough were significantly more sensitive to inhaled capsaicin and ATP and showed a change in relationship between urge-to-cough perception and cough induction. When urge-to-cough levels were matched, participants with chronic cough displayed significantly less neural activation in medullary regions known to integrate airway sensory inputs. By contrast, neural activations did not differ significantly between the two groups in cortical brain regions known to encode cough sensations whereas activation in a midbrain region of participants with chronic cough was significantly increased compared to controls.

INTERPRETATION:

Cough hypersensitivity in some patients may occur in brain circuits above the level of the medulla, perhaps involving midbrain regions that amplify ascending sensory signals or change the efficacy of central inhibitory control systems that ordinarily serve to filter sensory inputs.

FUNDING:

Supported in part by a research grant from Investigator-Initiated Studies Program of Merck Sharp & Dohme Pty Ltd. The opinions expressed in this paper are those of the authors and do not necessarily represent those of Merck Sharp & Dohme (Australia) Pty Ltd.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Capsaicina / Hipersensibilidad Límite: Humans Idioma: En Revista: EBioMedicine Año: 2024 Tipo del documento: Article País de afiliación: Australia Pais de publicación: Países Bajos
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Capsaicina / Hipersensibilidad Límite: Humans Idioma: En Revista: EBioMedicine Año: 2024 Tipo del documento: Article País de afiliación: Australia Pais de publicación: Países Bajos