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Dynamic and selective engrams emerge with memory consolidation.
Tomé, Douglas Feitosa; Zhang, Ying; Aida, Tomomi; Mosto, Olivia; Lu, Yifeng; Chen, Mandy; Sadeh, Sadra; Roy, Dheeraj S; Clopath, Claudia.
Afiliación
  • Tomé DF; Department of Bioengineering, Imperial College London, London, UK. douglas.feitosatome@ist.ac.at.
  • Zhang Y; Institute of Science and Technology Austria, Klosterneuburg, Austria. douglas.feitosatome@ist.ac.at.
  • Aida T; McGovern Institute for Brain Research, Massachusetts Institute of Technology, Cambridge, MA, USA. y_zhang@mail.tsinghua.edu.cn.
  • Mosto O; Center for Life Sciences & IDG/McGovern Institute for Brain Research, School of Life Sciences, Tsinghua University, Beijing, China. y_zhang@mail.tsinghua.edu.cn.
  • Lu Y; McGovern Institute for Brain Research, Massachusetts Institute of Technology, Cambridge, MA, USA.
  • Chen M; McGovern Institute for Brain Research, Massachusetts Institute of Technology, Cambridge, MA, USA.
  • Sadeh S; Center for Life Sciences & IDG/McGovern Institute for Brain Research, School of Life Sciences, Tsinghua University, Beijing, China.
  • Roy DS; McGovern Institute for Brain Research, Massachusetts Institute of Technology, Cambridge, MA, USA.
  • Clopath C; Department of Bioengineering, Imperial College London, London, UK.
Nat Neurosci ; 27(3): 561-572, 2024 Mar.
Article en En | MEDLINE | ID: mdl-38243089
ABSTRACT
Episodic memories are encoded by experience-activated neuronal ensembles that remain necessary and sufficient for recall. However, the temporal evolution of memory engrams after initial encoding is unclear. In this study, we employed computational and experimental approaches to examine how the neural composition and selectivity of engrams change with memory consolidation. Our spiking neural network model yielded testable predictions memories transition from unselective to selective as neurons drop out of and drop into engrams; inhibitory activity during recall is essential for memory selectivity; and inhibitory synaptic plasticity during memory consolidation is critical for engrams to become selective. Using activity-dependent labeling, longitudinal calcium imaging and a combination of optogenetic and chemogenetic manipulations in mouse dentate gyrus, we conducted contextual fear conditioning experiments that supported our model's predictions. Our results reveal that memory engrams are dynamic and that changes in engram composition mediated by inhibitory plasticity are crucial for the emergence of memory selectivity.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Memoria Episódica / Consolidación de la Memoria Tipo de estudio: Prognostic_studies Límite: Animals Idioma: En Revista: Nat Neurosci Asunto de la revista: NEUROLOGIA Año: 2024 Tipo del documento: Article País de afiliación: Reino Unido Pais de publicación: Estados Unidos
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Memoria Episódica / Consolidación de la Memoria Tipo de estudio: Prognostic_studies Límite: Animals Idioma: En Revista: Nat Neurosci Asunto de la revista: NEUROLOGIA Año: 2024 Tipo del documento: Article País de afiliación: Reino Unido Pais de publicación: Estados Unidos