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A transcriptomic analysis in mice following a single dose of ibogaine identifies new potential therapeutic targets.
Biosca-Brull, Judit; Ona, Genis; Alarcón-Franco, Lineth; Colomina, Maria Teresa.
Afiliación
  • Biosca-Brull J; Universitat Rovira i Virgili, Research Group in Neurobehavior and Health (NEUROLAB), Tarragona, Spain.
  • Ona G; Universitat Rovira i Virgili, Department of Psychology and Research Center for Behavior Assessment (CRAMC), Tarragona, Spain.
  • Alarcón-Franco L; Universitat Rovira i Virgili, Center of Environmental, Food and Toxicological Technology (TECNATOX), Reus, Spain.
  • Colomina MT; ICEERS-International Center for Ethnobotanical Education, Research, and Services, Barcelona, Spain.
Transl Psychiatry ; 14(1): 41, 2024 Jan 19.
Article en En | MEDLINE | ID: mdl-38242896
ABSTRACT
Ibogaine (IBO) is an atypical psychedelic with a complex mechanism of action. To date, the mechanisms that may underlie its anti-addictive effects are still not defined. This study aims to identify changes in gene expression induced by a single oral dose of IBO in the cortex of mice by means of a transcriptomic analysis for the first time. Our results showed significant alterations in gene expression in mouse frontal cortex samples 4 h after a single oral dose of IBO. Specifically, genes involved in hormonal pathways and synaptogenesis exhibited upregulation, while genes associated with apoptotic processes and endosomal transports showed downregulation. The findings were further corroborated through quantitative polymerase chain reaction (qPCR) analysis. However, the validation of gene expression related to hormonal pathways did not entirely align with the transcriptomic analysis results, possibly due to the brain region from which tissue was collected. Sex differences were observed, with female mice displaying more pronounced alterations in gene expression after IBO treatment. High variability was observed across individual animals. However, this study represents a significant advancement in comprehending IBO's molecular actions. The findings highlight the influence of IBO on gene expression, particularly on hormonal pathways, synaptogenesis, apoptotic processes, and endosomal transports. The identification of sex differences underscores the importance of considering sex as a potential factor influencing IBO's effects. Further research to assess different time points after IBO exposure is warranted.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Alucinógenos / Ibogaína Tipo de estudio: Prognostic_studies Límite: Animals Idioma: En Revista: Transl Psychiatry Año: 2024 Tipo del documento: Article País de afiliación: España Pais de publicación: Estados Unidos
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Alucinógenos / Ibogaína Tipo de estudio: Prognostic_studies Límite: Animals Idioma: En Revista: Transl Psychiatry Año: 2024 Tipo del documento: Article País de afiliación: España Pais de publicación: Estados Unidos