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Current paradigms in employing self-assembled structures: Drug delivery implications with improved therapeutic potential.
Sharma, Ajay; Singh, Manoj; Sharma, Varruchi; Vashishth, Amit; Raj, Mayank; Upadhyay, Sushil K; Singh, Sandeep; Ramniwas, Seema; Dhama, Kuldeep; Sharma, Anil K; Bhatia, Shashi Kant.
Afiliación
  • Sharma A; Department of Chemistry, Career Point University, Tikker - Kharwarian, Hamirpur, Himachal Pradesh 176041, India; Center for Nanoscience and Technology, Career Point University, Tikker - Kharwarian, Hamirpur, Himachal Pradesh, 176041, India. Electronic address: ajayansu1@gmail.com.
  • Singh M; Department of Bio-sciences and Technology, Maharishi Markandeshwar (Deemed to be University), Mullana, Ambala, Haryana 133207, India. Electronic address: lookformanoj@gmail.com.
  • Sharma V; Department of Biotechnology & Bioinformatics, Sri Guru Gobind Singh College, Chandigarh 160019, India. Electronic address: sharma.varruchi@gmail.com.
  • Vashishth A; Department of Science and Humanities, SRM Institute of Science & Technology (Deemed to be University) Delhi-NCR Campus, Ghaziabad, UP 201204, India. Electronic address: amitvashishth659@gmail.com.
  • Raj M; Department of Bio-sciences and Technology, Maharishi Markandeshwar (Deemed to be University), Mullana, Ambala, Haryana 133207, India. Electronic address: rajmayank9162@gmail.com.
  • Upadhyay SK; Department of Bio-sciences and Technology, Maharishi Markandeshwar (Deemed to be University), Mullana, Ambala, Haryana 133207, India. Electronic address: upadhyay.k.sushil@gmail.com.
  • Singh S; Department of Chemistry, Sri Guru Gobind Singh College, Sector -26, Chandigarh, India. Electronic address: sandeepiitr8@gmail.com.
  • Ramniwas S; University Centre for Research and Development, University Institute of Biotechnology Chandigarh University, Gharuan, Mohali, India. Electronic address: seema.ramniwas@gmail.com.
  • Dhama K; Division of Pathology, ICAR-Indian Veterinary Research Institute, Izatnagar, UP, India. Electronic address: kdhama@rediffmail.com.
  • Sharma AK; Department of Biotechnology, Amity University, Sector 82 A, IT City Rd, Block D, Sahibzada Ajit Singh Nagar, Punjab, 140306, India. Electronic address: anibiotech18@gmail.com.
  • Bhatia SK; Biotransformation and Biomaterials Lab, Department of Biological Engineering, College of Engineering, KonkukUniversity, Hwayang-dong Gwangjin-gu, Seoul 05029, South Korea. Electronic address: shashibiotechhpu@gmail.com.
Colloids Surf B Biointerfaces ; 234: 113745, 2024 Feb.
Article en En | MEDLINE | ID: mdl-38241890
ABSTRACT
Recent efforts have focused on developing improved drug delivery systems with enhanced therapeutic efficacy and minimal side effects. Micelles, self-assembled from amphiphilic block copolymers in aqueous solutions, have gained considerable attention for drug delivery. However, there is a need to further enhance their efficiency. These micelles offer benefits like biodegradability, biocompatibility, sustained drug release, and improved patient compliance. Yet, researchers must address stability issues and reduce toxicity. Nanoscale self-assembled structures have shown promise as efficient drug carriers, offering an alternative to conventional methods. Fine-tuning at the monomeric and molecular levels, along with structural modifications, is crucial for optimal drug release profiles. Various strategies, such as entrapping hydrophobic drugs and using polyethylene oxide diblock copolymer micelles to resist protein adsorption and cellular adhesion, protect the hydrophobic core from degradation. The polyethylene oxide corona also provides stealth properties, prolonging blood circulation for extended drug administration. Amphiphilic copolymers are attractive for drug delivery due to their adjustable properties, allowing control over micelle size and morphology. Emerging tools promise complex and multifunctional platforms. This article summarizes about the challenges as far as the use of micelles is concerned, including optimizing performance, rigorous pre-clinical and clinical research, and suggests further improvement for drug delivery efficacy.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Sistemas de Liberación de Medicamentos / Micelas Límite: Humans Idioma: En Revista: Colloids Surf B Biointerfaces Asunto de la revista: QUIMICA Año: 2024 Tipo del documento: Article Pais de publicación: Países Bajos
Texto completo
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Imprimir
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Sistemas de Liberación de Medicamentos / Micelas Límite: Humans Idioma: En Revista: Colloids Surf B Biointerfaces Asunto de la revista: QUIMICA Año: 2024 Tipo del documento: Article Pais de publicación: Países Bajos