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Colchicine-intolerant familial mediterranean fever patients: A comparative study between different colchicine doses and IL-1 inhibitor monotherapy.
Yildirim, Derya; Kardas, Riza Can; Gun, Mert; Kaya, Burcugul; Vasi, Ibrahim; Duran, Rahime; Karadeniz, Hazan; Avanoglu Guler, Aslihan; Kucuk, Hamit; Erden, Abdulsamet; Goker, Berna; Ozturk, Mehmet Akif; Tufan, Abdurrahman.
Afiliación
  • Yildirim D; Gazi University Faculty of Medicine, Department of Internal Medicine, Division of Rheumatology, Turkey. Electronic address: deryaakdeniz1@gmail.com.
  • Kardas RC; Gazi University Faculty of Medicine, Department of Internal Medicine, Division of Rheumatology, Turkey.
  • Gun M; Gazi University Faculty of Medicine, Department of Internal Medicine, Division of Rheumatology, Turkey.
  • Kaya B; Gazi University Faculty of Medicine, Department of Internal Medicine, Division of Rheumatology, Turkey.
  • Vasi I; Gazi University Faculty of Medicine, Department of Internal Medicine, Division of Rheumatology, Turkey.
  • Duran R; Gazi University Faculty of Medicine, Department of Internal Medicine, Division of Rheumatology, Turkey.
  • Karadeniz H; Gazi University Faculty of Medicine, Department of Internal Medicine, Division of Rheumatology, Turkey.
  • Avanoglu Guler A; Gazi University Faculty of Medicine, Department of Internal Medicine, Division of Rheumatology, Turkey.
  • Kucuk H; Gazi University Faculty of Medicine, Department of Internal Medicine, Division of Rheumatology, Turkey.
  • Erden A; Gazi University Faculty of Medicine, Department of Internal Medicine, Division of Rheumatology, Turkey.
  • Goker B; Gazi University Faculty of Medicine, Department of Internal Medicine, Division of Rheumatology, Turkey.
  • Ozturk MA; Gazi University Faculty of Medicine, Department of Internal Medicine, Division of Rheumatology, Turkey.
  • Tufan A; Gazi University Faculty of Medicine, Department of Internal Medicine, Division of Rheumatology, Turkey.
Int Immunopharmacol ; 128: 111491, 2024 Feb 15.
Article en En | MEDLINE | ID: mdl-38241844
ABSTRACT

OBJECTIVE:

Familial Mediterranean fever (FMF) is the most common monogenic autoinflammatory disease. Colchicine is the primary treatment for FMF, although some patients do not respond well or are unable to tolerate it. For these patients, the addition of interleukin-1 (IL-1) antagonists is the preferred option. However, the impact of colchicine treatment alongside the use of IL-1 antagonists remains unclear.

METHODS:

We recruited adult FMF patients who satisfied the Eurofever and Pediatric Rheumatology International Trials Organization classification criteria and were receiving IL-1 antagonist treatment from our FMF cohort. All the patients exhibited colchicine intolerance or resistance. As per the FMF cohort protocol, the patients were longitudinally followed up, including assessments of their C-reactive protein, erythrocyte sedimentation rate, autoinflammatory disease activity index (AIDAI), and autoinflammatory damage index (ADDI).

RESULTS:

Among the 125 patients (68 female and 57 male), 96 received a combination of IL-1 antagonists and the maximum tolerated dose of colchicine, whereas 29 were treated exclusively with IL-1 antagonists due to colchicine intolerance. The patients' inflammatory markers, AIDAI activity, and ADDI damage scores did not differ significantly between the two groups during the follow-up period. Notably, the drug retention rates were significantly higher in the patients treated solely with IL-1 antagonists.

CONCLUSION:

While the typical approach is to maintain colchicine treatment alongside the use of IL-1 antagonists, for patients who cannot tolerate effective colchicine doses, IL-1 antagonists alone may effectively control FMF disease activity.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Fiebre Mediterránea Familiar Tipo de estudio: Guideline Límite: Adult / Child / Female / Humans / Male Idioma: En Revista: Int Immunopharmacol Asunto de la revista: ALERGIA E IMUNOLOGIA / FARMACOLOGIA Año: 2024 Tipo del documento: Article Pais de publicación: Países Bajos
Texto completo
Añadir a Mi BVS
Imprimir
XML
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Fiebre Mediterránea Familiar Tipo de estudio: Guideline Límite: Adult / Child / Female / Humans / Male Idioma: En Revista: Int Immunopharmacol Asunto de la revista: ALERGIA E IMUNOLOGIA / FARMACOLOGIA Año: 2024 Tipo del documento: Article Pais de publicación: Países Bajos