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Integrated-mode proton radiography with 2D lateral projections.
Simard, Mikaël; Robertson, Daniel G; Fullarton, Ryan; Royle, Gary; Beddar, Sam; Collins-Fekete, Charles-Antoine.
Afiliación
  • Simard M; Department of Medical Physics and Biomedical Engineering, University College London, London, United Kingdom.
  • Robertson DG; Division of Medical Physics, Department of Radiation Oncology, Mayo Clinic Arizona, 5881 E Mayo Blvd, Phoenix, AZ, United States of America.
  • Fullarton R; Department of Medical Physics and Biomedical Engineering, University College London, London, United Kingdom.
  • Royle G; Department of Medical Physics and Biomedical Engineering, University College London, London, United Kingdom.
  • Beddar S; The University of Texas MD Anderson UTHealth Graduate School of Biomedical Sciences, Houston, TX, United States of America.
  • Collins-Fekete CA; Department of Medical Physics and Biomedical Engineering, University College London, London, United Kingdom.
Phys Med Biol ; 69(5)2024 Feb 27.
Article en En | MEDLINE | ID: mdl-38241716
ABSTRACT
Integrated-mode proton radiography leading to water equivalent thickness (WET) maps is an avenue of interest for motion management, patient positioning, andin vivorange verification. Radiographs can be obtained using a pencil beam scanning setup with a large 3D monolithic scintillator coupled with optical cameras. Established reconstruction methods either (1) involve a camera at the distal end of the scintillator, or (2) use a lateral view camera as a range telescope. Both approaches lead to limited image quality. The purpose of this work is to propose a third, novel reconstruction framework that exploits the 2D information provided by two lateral view cameras, to improve image quality achievable using lateral views. The three methods are first compared in a simulated Geant4 Monte Carlo framework using an extended cardiac torso (XCAT) phantom and a slanted edge. The proposed method with 2D lateral views is also compared with the range telescope approach using experimental data acquired with a plastic volumetric scintillator. Scanned phantoms include a Las Vegas (contrast), 9 tissue-substitute inserts (WET accuracy), and a paediatric head phantom. Resolution increases from 0.24 (distal) to 0.33 lp mm-1(proposed method) on the simulated slanted edge phantom, and the mean absolute error on WET maps of the XCAT phantom is reduced from 3.4 to 2.7 mm with the same methods. Experimental data from the proposed 2D lateral views indicate a 36% increase in contrast relative to the range telescope method. High WET accuracy is obtained, with a mean absolute error of 0.4 mm over 9 inserts. Results are presented for various pencil beam spacing ranging from 2 to 6 mm. This work illustrates that high quality proton radiographs can be obtained with clinical beam settings and the proposed reconstruction framework with 2D lateral views, with potential applications in adaptive proton therapy.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Protones / Terapia de Protones Límite: Child / Humans Idioma: En Revista: Phys Med Biol Año: 2024 Tipo del documento: Article País de afiliación: Reino Unido Pais de publicación: Reino Unido
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Protones / Terapia de Protones Límite: Child / Humans Idioma: En Revista: Phys Med Biol Año: 2024 Tipo del documento: Article País de afiliación: Reino Unido Pais de publicación: Reino Unido