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Hox genes control homocercal caudal fin development and evolution.
Cumplido, Nicolás; Arratia, Gloria; Desvignes, Thomas; Muñoz-Sánchez, Salomé; Postlethwait, John H; Allende, Miguel L.
Afiliación
  • Cumplido N; Millennium Institute Center for Genome Regulation, Facultad de Ciencias, Universidad de Chile, Santiago, Chile.
  • Arratia G; University of Kansas, Department of Ecology and Evolutionary Biology and Biodiversity Institute, Lawrence, KS, USA.
  • Desvignes T; Institute of Neuroscience, University of Oregon, Eugene, OR, USA.
  • Muñoz-Sánchez S; Millennium Institute Center for Genome Regulation, Facultad de Ciencias, Universidad de Chile, Santiago, Chile.
  • Postlethwait JH; Institute of Neuroscience, University of Oregon, Eugene, OR, USA.
  • Allende ML; Millennium Institute Center for Genome Regulation, Facultad de Ciencias, Universidad de Chile, Santiago, Chile.
Sci Adv ; 10(3): eadj5991, 2024 Jan 19.
Article en En | MEDLINE | ID: mdl-38241378
ABSTRACT
Ancient bony fishes had heterocercal tails, like modern sharks and sturgeons, with asymmetric caudal fins and a vertebral column extending into an elongated upper lobe. Teleost fishes, in contrast, developed a homocercal tail characterized by two separate equal-sized fin lobes and the body axis not extending into the caudal fin. A similar heterocercal-to-homocercal transition occurs during teleost ontogeny, although the underlying genetic and developmental mechanisms for either transition remain unresolved. Here, we investigated the role of hox13 genes in caudal fin formation as these genes control posterior identity in animals. Analysis of expression profiles of zebrafish hox13 paralogs and phenotypes of CRISPR/Cas9-induced mutants showed that double hoxb13a and hoxc13a mutants fail to form a caudal fin. Furthermore, single mutants display heterocercal-like morphologies not seen since Mesozoic fossil teleosteomorphs. Relaxation of functional constraints after the teleost genome duplication may have allowed hox13 duplicates to neo- or subfunctionalize, ultimately contributing to the evolution of a homocercal tail in teleost fishes.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Pez Cebra / Evolución Biológica Límite: Animals Idioma: En Revista: Sci Adv Año: 2024 Tipo del documento: Article País de afiliación: Chile Pais de publicación: Estados Unidos
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Pez Cebra / Evolución Biológica Límite: Animals Idioma: En Revista: Sci Adv Año: 2024 Tipo del documento: Article País de afiliación: Chile Pais de publicación: Estados Unidos