A solid-state NMR method for characterization of pharmaceutical eutectics.

Hareendran, Chaithanya; Shaligram, Parth S; Gonnade, Rajesh; Ajithkumar, T G

Hareendran, Chaithanya; Shaligram, Parth S; Gonnade, Rajesh; Ajithkumar, T G.

Afiliación

Hareendran C; Central NMR facility and Physical/Materials Chemistry Division, CSIR-National Chemical Laboratory, Pune 411008, India. tg.ajithkumar@ncl.res.in.
Shaligram PS; Academy of Scientific and Innovative Research (AcSIR), Ghaziabad 201002, India.
Gonnade R; Academy of Scientific and Innovative Research (AcSIR), Ghaziabad 201002, India.
Ajithkumar TG; Physical/Materials Chemistry Division, CSIR-National Chemical Laboratory, Pune 411008, India.

Phys Chem Chem Phys ; 26(5): 3800-3803, 2024 Jan 31.

Article en En | MEDLINE | ID: mdl-38240042

ABSTRACT

ABSTRACT

Pharmaceutical eutectics are extremely useful for designing formulations, and currently, there are no techniques other than differential scanning calorimetry (DSC) that can confirm their formation. In this study, we demonstrate that 1H fast magic angle spinning (MAS) solid-state NMR (SSNMR) experiments can confirm the formation of eutectics by detecting their intermolecular hydrogen bonding interactions.

Asunto(s)

Imagen por Resonancia Magnética; Espectroscopía de Resonancia Magnética/métodos; Composición de Medicamentos; Preparaciones Farmacéuticas

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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Imagen por Resonancia Magnética Idioma: En Revista: Phys Chem Chem Phys Asunto de la revista: BIOFISICA / QUIMICA Año: 2024 Tipo del documento: Article País de afiliación: India Pais de publicación: Reino Unido

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