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Maternal Exposure to Stress During Covid-19 and Non-Syndromic Orofacial Clefts: A Cohort Retrospective Study.
Sabbagh, Heba Jafar; AlSharif, Mona Talal; Abdulhameed, Fatma Dawood; Aljohar, Aziza Johar; Alhussain, Reema Mahdi; Alghamdi, Sultan Musaad; Alrejaye, Najla Sulaiman; AlGudaibi, Latifa Yousef; Sallout, Bahauddin Ibraheem; Albaqawi, Badi Shoaib; Alnamnakani, Eman Abdulbaset; Brekeit, Lougin Khalid; Basri, Osama Adel; Almalik, Manal Ibrahim; Al Soqih, Norah Suliman; Alshaikh, Ali Bakr; Aburiziza, Abdullah Jameel; Al Qahtani, Faisal Ali; Alghamdi, Bushra Musaad; Alraddadi, Asalah Khalid; Khaja, Hadeel Hamza; Alamoudi, Rana Abdullah.
Afiliación
  • Sabbagh HJ; Pediatric Dentistry Department, Faculty of Dentistry, King Abdulaziz University, Jeddah, Saudi Arabia.
  • AlSharif MT; Department of Dental Public Health, Faculty of Dentistry, King Abdulaziz University, Jeddah, Saudi Arabia.
  • Abdulhameed FD; Pediatric Surgery Department, King Salman Medical City, Maternity and Children's Hospital, Madinah, Saudi Arabia.
  • Aljohar AJ; Consultant Pedodontist, Department of Dentistry, King Faisal Specialist Hospital and Research Centre, Riyadh, Saudi Arabia.
  • Alhussain RM; Pediatric Dentistry Department, Dammam Medical Complex, Eastern Province, Saudi Arabia.
  • Alghamdi SM; Pediatric Dentistry Department, Bisha Dental Centre, Ministry of Health, Bisha, Saudi Arabia.
  • Alrejaye NS; Preventive Dental Science Department, College of Dentistry, King Saud bin Abdulaziz University for Health Sciences, Riyadh, Saudi Arabia.
  • AlGudaibi LY; Resident in the Saudi Board of Orthodontics and Dentofacial Orthopedics Program, King Abdulaziz Medical City, Ministry of National Guard Health Affairs; King Saud bin Abdulaziz University for Health Sciences, College of Dentistry; King Abdullah International Medical Research Center, Riyadh, Saudi Ar
  • Sallout BI; Consultant in Obstetrics and Gynecology, Maternal Fetal Medicine, Women's Specialized Hospital, King Fahad Medical City, Riyadh, Saudi Arabia.
  • Albaqawi BS; Consultant, Maternal Fetal Medicine, Women's Specialized Hospital, King Fahad Medical City, Riyadh, Saudi Arabia.
  • Alnamnakani EA; Consultant Orthodontist, Dental Department, Prince Sultan Military Medical City, Riyadh, Saudi Arabia.
  • Brekeit LK; Orthodontic Resident, Orthodontics and Dentofacial Orthopedics, Prince Sultan Military Medical City, Riyadh, Saudi Arabia.
  • Basri OA; Craniofacial Orthodontists, King Faisal Specialist Hospital and Research Centre, Jeddah, Saudi Arabia.
  • Almalik MI; Consultant Pedodontist, Dental Department, King Fahad Armed Forces Hospital, Jeddah, Saudi Arabia.
  • Al Soqih NS; Department of Pediatrics, Qassim University, College of Medicine, Buraidah, Saudi Arabia.
  • Alshaikh AB; Resident in Pediatric Dentistry, Faculty of Dentistry, King Abdulaziz University, Jeddah, Saudi Arabia.
  • Aburiziza AJ; Pediatric Department, Faculty of Medicine, Umm Al-Qura University, Makkah, Saudi Arabia.
  • Al Qahtani FA; Pediatric Dentistry Department, Faculty of Dentistry, King Khalid University, Abha, Saudi Arabia.
  • Alghamdi BM; Faculty of Medicine, Al-Baha University, Al-Baha, Saudi Arabia.
  • Alraddadi AK; Faculty of Dentistry, King Abdulaziz University, Jeddah, Saudi Arabia.
  • Khaja HH; Center of Congenital Malformations in Fetuses and Newborns, King Salman bin Abdulaziz Medical City, Madinah, Saudi Arabia.
  • Alamoudi RA; Pediatric Dentistry Department, Faculty of Dentistry, King Abdulaziz University, Jeddah, Saudi Arabia.
Cleft Palate Craniofac J ; : 10556656231224198, 2024 Jan 18.
Article en En | MEDLINE | ID: mdl-38239006
ABSTRACT

OBJECTIVE:

The coronavirus (COVID-19) pandemic presents an opportunity to study stress's effect on the development of non-syndromic orofacial clefts (NSOFCs). This study was aimed at assessing maternal stress exposure during the pregestational to first trimester pregnancy periods and the development of NSOFCs during a year of the COVID-19 pandemic.

DESIGN:

Cohort study of infants with NSOFCs and controls matched based on recruitment site and age.

SETTING:

Government hospitals in Saudi Arabia between November 2020 and November 2021. MAIN OUTCOME

MEASURES:

Data collection included NSOFC clinical examination and maternal stress exposure assessment using the Modified Life Events Questionnaire, the Fear of COVID-19 Scale, and a focus on the lack of pregnancy planning and a threatened miscarriage.

RESULTS:

Of the 557 infants recruited, 191 had NSOFCs. Logistic regression analysis with adjusted odds ratios (AORs) that removed the effects of confounders showed that any of the seven stressful life events (AOR3.78, P < .001) and the family histories of relatives with NSOFCs (AOR9.73, P < .001) increased the AOR for NSOFC development. In contrast, maternal folic acid (AOR0.56, P.010), threatened miscarriage (AOR0.17, P = .001), fear of COVID-19 (AOR0.83, P = .038), and suspected COVID-19 infection (AOR0.43, P = .008) decreased the AOR for NSOFC development.

CONCLUSION:

Along with an established risk associated with family history of birth defects, stressful life events may be a risk factor for NSOFC development. Beyond folic acid's known benefit, it may be that higher maternal health concerns contribute to increased protective health behaviors during pregnancy. Ongoing research is needed to specify the maternal risk factors for NSOFC.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Tipo de estudio: Etiology_studies / Observational_studies / Risk_factors_studies Idioma: En Revista: Cleft Palate Craniofac J Asunto de la revista: ODONTOLOGIA Año: 2024 Tipo del documento: Article País de afiliación: Arabia Saudita Pais de publicación: Estados Unidos
Texto completo
Añadir a Mi BVS
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Tipo de estudio: Etiology_studies / Observational_studies / Risk_factors_studies Idioma: En Revista: Cleft Palate Craniofac J Asunto de la revista: ODONTOLOGIA Año: 2024 Tipo del documento: Article País de afiliación: Arabia Saudita Pais de publicación: Estados Unidos