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Hospitalized acute exacerbation in chronic obstructive pulmonary disease - impact on long-term renal outcomes.
Kwok, Wang Chun; Tam, Terence C C; Ho, James C M; Lam, David C L; Ip, Mary S M; Yap, Desmond Y H.
Afiliación
  • Kwok WC; Division of Respiratory Medicine, The University of Hong Kong, Hong Kong SAR, People's Republic of China.
  • Tam TCC; Division of Respiratory Medicine, The University of Hong Kong, Hong Kong SAR, People's Republic of China.
  • Ho JCM; Division of Respiratory Medicine, The University of Hong Kong, Hong Kong SAR, People's Republic of China.
  • Lam DCL; Division of Respiratory Medicine, The University of Hong Kong, Hong Kong SAR, People's Republic of China.
  • Ip MSM; Division of Respiratory Medicine, The University of Hong Kong, Hong Kong SAR, People's Republic of China.
  • Yap DYH; Division of Nephrology, Department of Medicine, Queen Mary Hospital, the University of Hong Kong, Hong Kong Special Administrative Region, Hong Kong SAR, People's Republic of China. desmondy@hku.hk.
Respir Res ; 25(1): 36, 2024 Jan 18.
Article en En | MEDLINE | ID: mdl-38238804
ABSTRACT

INTRODUCTION:

Acute exacerbation of chronic obstructive pulmonary disease (AECOPD) is a common and preventable event in patients with chronic obstructive pulmonary disease (COPD). Data regarding the impact of AECOPD on short- and long-term renal outcomes are lacking.

METHODS:

We included all COPD patients who were followed at Queen Mary Hospital (QMH) in year 2015 and reviewed their clinical/renal outcomes in subsequent five years. Relationships between AECOPD and adverse renal outcomes were evaluated.

RESULTS:

371 COPD patients were included. 169 patients had hospitalized AECOPD in past one year (HAE group) while 202 patients did not (non-HAE group). 285 patients (76.8%) had renal progression/death and 102 (27.5%) patients developed acute kidney injury (AKI). HAE group showed a more rapid eGFR decline than non-HAE group (-4.64 mL/min/1.73m2/year vs. -2.40 mL/min/1.73m2/year, p = 0.025). HAE group had significantly higher risk for renal progression/death at 5 years [adjusted OR (aOR) 2.380 (95% CI = 1.144-4.954), p = 0.020]. The frequency of hospitalized AECOPD in past 3 years, any AECOPD in past 3 years, hospitalized AECOPD in past 3 years were also predictive of renal progression/death at 5 years [aOR were 1.176 (95% CI = 1.038- 1.331), 2.998 (95% CI = 1.438-6.250) and 2.887 (95% CI = 1.409-5.917) respectively; p = 0.011, 0.003 and 0.004]. HAE group also showed significantly higher risk of AKI [adjusted HR (aHR) 2.430; 95% CI = 1.306-4.519, p = 0.005].

CONCLUSIONS:

AECOPD, in particular HAE, was associated with increased risk of renal progression/death and AKI. Prevention of AECOPD, especially HAE, may potentially improve short- and long-term renal outcomes in COPD patients.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Enfermedad Pulmonar Obstructiva Crónica / Lesión Renal Aguda Tipo de estudio: Diagnostic_studies / Prognostic_studies Límite: Humans Idioma: En Revista: Respir Res Año: 2024 Tipo del documento: Article Pais de publicación: Reino Unido
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Enfermedad Pulmonar Obstructiva Crónica / Lesión Renal Aguda Tipo de estudio: Diagnostic_studies / Prognostic_studies Límite: Humans Idioma: En Revista: Respir Res Año: 2024 Tipo del documento: Article Pais de publicación: Reino Unido