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Impact of Pleural Lavage Cytology Positivity on Early Recurrence After Surgery for Non-Small Cell Lung Cancer.
Recuero Díaz, José Luis; Gatius Caldero, Sonia; Rosado Rodríguez, Joel; Caamaño Villaverde, Verónica; Gómez de Antonio, David; Tejerina, Eva; Sánchez Moreno, Laura; Martino González, María; Moldes Rodríguez, Milagros; Abdulkader Nallib, Ihab; Ramírez Gil, Elena; Amat Villegas, Irene; Genovés Crespo, Marta; García Ángel, Rubén; Sampedro Salinas, Cora; Figueroa Almánzar, Santiago; Compañ Quilis, Amparo; Saumench Perramon, Roser; González Pont, Guadalupe; Royo Crespo, Íñigo; Gambó Grasa, Paula; García Fernández, José Luis; Jiménez Heffernan, José Antonio; Cerón Navarro, José; Prieto Rodríguez, Mireia; Porcel, José M.
Afiliación
  • Recuero Díaz JL; Department of Thoracic Surgery, Hospital Universitario Miguel Servet, Zaragoza, IIS Aragón, Spain. Electronic address: jl_recuero@hotmail.com.
  • Gatius Caldero S; Department of Pathology, Hospital Universitario Arnau de Vilanova, Lleida, Spain.
  • Rosado Rodríguez J; Department of Thoracic Surgery, Hospital Universitario de Cruces, Barakaldo, Spain.
  • Caamaño Villaverde V; Department of Pathology, Hospital Universitario de Cruces, Barakaldo, Spain.
  • Gómez de Antonio D; Department of Thoracic Surgery, Hospital Universitario Puerta de Hierro Majadahonda, Madrid, Spain.
  • Tejerina E; Department of Pathology, Hospital Universitario Puerta de Hierro Majadahonda, Madrid, Spain.
  • Sánchez Moreno L; Department of Thoracic Surgery, Hospital Universitario Marqués de Valdecilla, Santander, Spain.
  • Martino González M; Department of Pathology, Hospital Universitario Marqués de Valdecilla, Santander, Spain.
  • Moldes Rodríguez M; Department of Thoracic Surgery, Hospital Clínico Universitario de Santiago, Santiago de Compostela, Spain.
  • Abdulkader Nallib I; Department of Pathology, Hospital Clínico Universitario de Santiago, Santiago de Compostela, Spain.
  • Ramírez Gil E; Department of Thoracic Surgery, Hospital Universitario de Navarra, Pamplona, Spain.
  • Amat Villegas I; Department of Pathology, Hospital Universitario de Navarra, Pamplona, Spain.
  • Genovés Crespo M; Department of Thoracic Surgery, Complejo Hospitalario Universitario de Albacete, Albacete, Spain.
  • García Ángel R; Department of Pathology, Complejo Hospitalario Universitario de Albacete, Albacete, Spain.
  • Sampedro Salinas C; Department of Thoracic Surgery, Hospital Universitario Arnau de Vilanova, Lleida, Spain.
  • Figueroa Almánzar S; Department of Thoracic Surgery, Hospital Clínico Universitario de Valencia, Valencia, Spain.
  • Compañ Quilis A; Department of Pathology, Hospital Clínico Universitario de Valencia, Valencia, Spain.
  • Saumench Perramon R; Department of Thoracic Surgery, Hospital Universitari MútuaTerrassa, Terrassa, Barcelona, Spain.
  • González Pont G; Department of Pathology, Hospital Universitari MútuaTerrassa, Terrassa, Barcelona, Spain.
  • Royo Crespo Í; Department of Thoracic Surgery, Hospital Universitario Miguel Servet, Zaragoza, IIS Aragón, Spain.
  • Gambó Grasa P; Department of Pathology, Hospital Universitario Miguel Servet, Zaragoza, Spain.
  • García Fernández JL; Department of Thoracic Surgery, Hospital de La Princesa, Madrid, Spain.
  • Jiménez Heffernan JA; Department of Pathology, Hospital de La Princesa, Madrid, Spain.
  • Cerón Navarro J; Department of Thoracic Surgery, Hospital Universitario y Politécnico La Fe, Valencia, Spain.
  • Prieto Rodríguez M; Department of Pathology, Hospital Universitario y Politécnico La Fe, Valencia, Spain.
  • Porcel JM; Pleural Medicine Unit, Department of Internal Medicine, Hospital Universitario Arnau de Vilanova, Lleida, IRBLleida, Spain.
Arch Bronconeumol ; 60(3): 133-142, 2024 Mar.
Article en En, Es | MEDLINE | ID: mdl-38238188
ABSTRACT

OBJECTIVE:

The aim of this study was to elucidate the impact of pleural lavage cytology positivity on early recurrence in patients operated on non-small cell lung cancer (NSCLC).

METHODS:

This is a multicentre prospective cohort study of 684 patients undergoing an anatomical lung resection for NSCLC between October 2015 and October 2017 at 12 national centres. A pleural lavage was performed before and after lung resection. The association between the different predictors of early recurrence and PLC positivity was performed using univariate and multivariate logistic regression models. A propensity score analysis was performed by inverse probability weighting (IPSW) using average treatment effect (ATE) estimation to analyse the impact of PLC positivity on early recurrence.

RESULTS:

Overall PLC positivity was observed in 15 patients (2.2%). After two years, 193 patients (28.2%) relapsed, 182 (27.2%) with a negative PLC and 11 (73.3%) with a positive PLC (p<0.001). Factors associated to early recurrence were adenocarcinoma histology (OR=1.59, 95%CI 1.06-2.38, p=0.025), visceral pleural invasion (OR=1.59, 95%CI 1.04-2.4, p=0.03), lymph node involvement (OR=1.84, 95%CI 1.14-2.96, p=0.013), advanced pathological stage (OR=2.12, 95%CI 1.27-3.54, p=0.004) and PLC positivity (OR=4.14, 95%CI 1.25-16.36, p=0.028). After IPSW, PLC positivity was associated with an increased risk of early recurrence (OR=3.46, 95%CI 2.25-5.36, p<0.001).

CONCLUSIONS:

Positive pleural lavage cytology was found to be the strongest predictor of early recurrence.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Carcinoma de Pulmón de Células no Pequeñas / Neoplasias Pulmonares Tipo de estudio: Observational_studies / Prognostic_studies / Risk_factors_studies Límite: Humans Idioma: En / Es Revista: Arch Bronconeumol Año: 2024 Tipo del documento: Article Pais de publicación: España
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Carcinoma de Pulmón de Células no Pequeñas / Neoplasias Pulmonares Tipo de estudio: Observational_studies / Prognostic_studies / Risk_factors_studies Límite: Humans Idioma: En / Es Revista: Arch Bronconeumol Año: 2024 Tipo del documento: Article Pais de publicación: España