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BDNF-dependent signaling in the olfactory bulb modulates social recognition memory in mice.
de Castro, Caio M; Almeida-Santos, Ana F; Mansk, Lara M Z; Jaimes, Laura F; Cammarota, Martín; Pereira, Grace S.
Afiliación
  • de Castro CM; Núcleo de Neurociências, Departamento de Fisiologia e Biofísica, Instituto de Ciências Biológicas, Universidade Federal de Minas Gerais, Brazil.
  • Almeida-Santos AF; Departamento de Pesquisa e Desenvolvimento, Fundação Cristiano Varela. Faculdade de Minas- Faminas, Brazil.
  • Mansk LMZ; Núcleo de Neurociências, Departamento de Fisiologia e Biofísica, Instituto de Ciências Biológicas, Universidade Federal de Minas Gerais, Brazil.
  • Jaimes LF; Núcleo de Neurociências, Departamento de Fisiologia e Biofísica, Instituto de Ciências Biológicas, Universidade Federal de Minas Gerais, Brazil.
  • Cammarota M; Memory Research Laboratory, Brain Institute, Federal University of Rio Grande do, Norte, Brazil.
  • Pereira GS; Núcleo de Neurociências, Departamento de Fisiologia e Biofísica, Instituto de Ciências Biológicas, Universidade Federal de Minas Gerais, Brazil. Electronic address: grace@icb.ufmg.br.
Neurobiol Learn Mem ; 208: 107891, 2024 Feb.
Article en En | MEDLINE | ID: mdl-38237799
ABSTRACT
An operative olfactory bulb (OB) is critical to social recognition memory (SRM) in rodents, which involves identifying conspecifics. Furthermore, OB also allocates synaptic plasticity events related to olfactory memories in their intricate neural circuit. Here, we asked whether the OB is a target for brain-derived neurotrophic factor (BDNF), a well-known mediator of plasticity and memory. Adult ICR-CD1 male mice had their SRM evaluated under the inhibition of BDNF-dependent signaling directly in the OB. We also quantified the expression of BDNF in the OB, after SRM acquisition. Our results presented an amnesic effect of anti-BDNF administered 12 h post-training. Although the western blot showed no statistical difference in pro-BDNF and BDNF expression, the analysis of fluorescence intensity in slices suggests SRM acquisition decreases BDNF in the granular cell layer of the OB. Next, to test the ability of BDNF to rescue SRM deficit, we administered the human recombinant BDNF (rBDNF) directly in the OB of socially isolated (SI) mice. Unexpectedly, rBDNF did not rescue SRM in SI mice. Furthermore, BDNF and pro-BDNF expression in the OB was unchanged by SI. Our study reinforces the OB as a plasticity locus in memory-related events. It also adds SRM as another type of memory sensitive to BDNF-dependent signaling.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Bulbo Olfatorio / Factor Neurotrófico Derivado del Encéfalo Tipo de estudio: Prognostic_studies Límite: Animals / Humans / Male Idioma: En Revista: Neurobiol Learn Mem Asunto de la revista: BIOLOGIA / CIENCIAS DO COMPORTAMENTO / NEUROLOGIA Año: 2024 Tipo del documento: Article País de afiliación: Brasil Pais de publicación: Estados Unidos
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Bulbo Olfatorio / Factor Neurotrófico Derivado del Encéfalo Tipo de estudio: Prognostic_studies Límite: Animals / Humans / Male Idioma: En Revista: Neurobiol Learn Mem Asunto de la revista: BIOLOGIA / CIENCIAS DO COMPORTAMENTO / NEUROLOGIA Año: 2024 Tipo del documento: Article País de afiliación: Brasil Pais de publicación: Estados Unidos