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Clinical, Diagnostic, and Treatment Characteristics of Orbital Liposarcoma.
Wu, Wei; Kang, Xin; Fang, Wei; Li, Yueyue; Ma, Rui; Ma, Mingshen; Hei, Yan; Wang, Qi; Wang, Xiaoyi; Mu, Xuetao; Zhao, Shuixi; Yang, Xinji.
Afiliación
  • Wu W; From the Senior Department of Ophthalmology (W.W., X.K., Y.L., R.M., Y H., Q.W., X.W., X.Y.), 3rd Medical Center of Chinese PLA General Hospital, Beijing, China. Electronic address: wuwei1@301hospital.com.cn.
  • Kang X; From the Senior Department of Ophthalmology (W.W., X.K., Y.L., R.M., Y H., Q.W., X.W., X.Y.), 3rd Medical Center of Chinese PLA General Hospital, Beijing, China.
  • Fang W; National Clinical Research Center for Ocular Diseases (W.F.), Eye Hospital, Wenzhou Medical University, Wenzhou, China.
  • Li Y; From the Senior Department of Ophthalmology (W.W., X.K., Y.L., R.M., Y H., Q.W., X.W., X.Y.), 3rd Medical Center of Chinese PLA General Hospital, Beijing, China.
  • Ma R; From the Senior Department of Ophthalmology (W.W., X.K., Y.L., R.M., Y H., Q.W., X.W., X.Y.), 3rd Medical Center of Chinese PLA General Hospital, Beijing, China.
  • Ma M; Department of Ophthalmology (M.M.), Beijing Chao-yang Hospital, Capital Medical University, Beijing, China.
  • Hei Y; From the Senior Department of Ophthalmology (W.W., X.K., Y.L., R.M., Y H., Q.W., X.W., X.Y.), 3rd Medical Center of Chinese PLA General Hospital, Beijing, China.
  • Wang Q; From the Senior Department of Ophthalmology (W.W., X.K., Y.L., R.M., Y H., Q.W., X.W., X.Y.), 3rd Medical Center of Chinese PLA General Hospital, Beijing, China.
  • Wang X; From the Senior Department of Ophthalmology (W.W., X.K., Y.L., R.M., Y H., Q.W., X.W., X.Y.), 3rd Medical Center of Chinese PLA General Hospital, Beijing, China.
  • Mu X; Department of Radiology (X.M.), 3rd Medical Center of Chinese PLA General Hospital, Beijing, China.
  • Zhao S; Department of Radiation Oncology (S.Z.), 3rd Medical Center of Chinese PLA General Hospital, Beijing, China.
  • Yang X; From the Senior Department of Ophthalmology (W.W., X.K., Y.L., R.M., Y H., Q.W., X.W., X.Y.), 3rd Medical Center of Chinese PLA General Hospital, Beijing, China. Electronic address: yangxinji68@sina.com.
Am J Ophthalmol ; 262: 134-140, 2024 06.
Article en En | MEDLINE | ID: mdl-38237748
ABSTRACT

PURPOSE:

To clarify the clinical, diagnostic, and treatment characteristics of orbital liposarcoma.

DESIGN:

Retrospective observational case series.

METHODS:

A review was performed of electronic medical records, histopathology, radiological images, and follow-up information for 21 patients with orbital liposarcoma.

RESULTS:

The predominant clinical manifestation of this disease was painless exophthalmos. The most frequently encountered pathological types were well-differentiated and myxoid liposarcoma. Preoperative radiological images from 15 patients showed that orbital liposarcoma initially developed in extraocular muscle in 9 patients. Furthermore, all well-differentiated liposarcomas exhibited the radiographic characteristics of irregular and ill-defined adipose tissue, whereas only 12.5% of myxoid liposarcomas had the imaging characteristics. For the patients who exclusively underwent surgery, all of those with subtotal excisions experienced recurrence, 63.6% of marginal excisions recurred, and 50% of wide excisions resulted in recurrence. However, none of the patients who underwent marginal excisions or wide excisions combined with adjuvant radiotherapy exhibited recurrence. The analysis of magnetic resonance imaging findings in 3 patients who underwent neoadjuvant radiotherapy revealed that the tumor size remained stable in a patient with well-differentiated liposarcoma, whereas another patient with the same type of tumor exhibited a gradual increase in size. Conversely, a patient with myxoid liposarcoma experienced a significant reduction in tumor size following neoadjuvant radiotherapy.

CONCLUSION:

Orbital liposarcoma demonstrated a propensity for developing in the extraocular muscle. The radiological images of orbital well-differentiated liposarcomas were characterized by irregular and ill-defined adipose tissue. Surgery combined with radiotherapy demonstrated potential in reducing recurrence rates. Notably, orbital myxoid liposarcoma exhibited greater sensitivity to radiotherapy compared to well-differentiated liposarcoma.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Neoplasias Orbitales / Imagen por Resonancia Magnética / Liposarcoma Tipo de estudio: Diagnostic_studies Límite: Adult / Aged / Aged80 / Female / Humans / Male / Middle aged Idioma: En Revista: Am J Ophthalmol Año: 2024 Tipo del documento: Article Pais de publicación: Estados Unidos
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Neoplasias Orbitales / Imagen por Resonancia Magnética / Liposarcoma Tipo de estudio: Diagnostic_studies Límite: Adult / Aged / Aged80 / Female / Humans / Male / Middle aged Idioma: En Revista: Am J Ophthalmol Año: 2024 Tipo del documento: Article Pais de publicación: Estados Unidos