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Pan-cancer Analysis Identifies AIMP2 as a Potential Biomarker for Breast Cancer.
Qiu, Jie; Zhou, Tao; Wang, Danhong; Hong, Weimin; Qian, Da; Meng, Xuli; Liu, Xiaozhen.
Afiliación
  • Qiu J; Department of Breast and Thyroid Surgery, Shaoxing People's Hospital, Shaoxing 312000, Zhejiang, China.
  • Zhou T; General Surgery, Cancer Center, Department of Breast Surgery, Zhejiang Provincial People's Hospital, Hangzhou Medical College, Hangzhou 310000, Zhejiang, China.
  • Wang D; College of Pharmacy, Zhejiang University of Technology, Hangzhou 310014, Zhejiang, China.
  • Hong W; General Surgery, Cancer Center, Department of Breast Surgery, Zhejiang Provincial People's Hospital, Hangzhou Medical College, Hangzhou 310000, Zhejiang, China.
  • Qian D; Department of Burn and Plastic Surgery-Hand Surgery, Changshu Hospital Affiliated to Soochow University, Changshu No.1 People's Hospital, Changshu 215500, Jiangsu Province, China.
  • Meng X; General Surgery, Cancer Center, Department of Breast Surgery, Zhejiang Provincial People's Hospital, Hangzhou Medical College, Hangzhou 310000, Zhejiang, China.
  • Liu X; General Surgery, Cancer Center, Department of Breast Surgery, Zhejiang Provincial People's Hospital, Hangzhou Medical College, Hangzhou 310000, Zhejiang, China.
Curr Genomics ; 24(5): 307-329, 2023 Dec 20.
Article en En | MEDLINE | ID: mdl-38235352
ABSTRACT

Introduction:

Aminoacyl tRNA synthetase complex interacting with multifunctional protein 2 (AIMP2) is a significant regulator of cell proliferation and apoptosis. Despite its abnormal expression in various tumor types, the specific functions and effects of AIMP2 on tumor immune cell infiltration, proliferation, and migration remain unclear. Materials and

Methods:

To assess AIMP2's role in tumor immunity, we conducted a pan-cancer multi-database analysis using the Cancer Genome Atlas (TCGA), Genotype-Tissue Expression (GTEx), and Cancer Cell Lines Encyclopedia (CCLE) datasets, examining expression levels, prognosis, tumor progression, and immune microenvironment. Additionally, we investigated AIMP2's impact on breast cancer (BRCA) proliferation and migration using cell counting kit 8 (CCK-8) assay, transwell assays, and western blot analysis.

Results:

Our findings revealed that AIMP2 was overexpressed in 24 tumor tissue types compared to normal tissue and was associated with four tumor stages. Survival analysis indicated that AIMP2 expression was strongly correlated with overall survival (OS) in certain cancer patients, with high AIMP2 expression linked to poorer prognosis in five cancer types.

Conclusion:

Finally, siRNA-mediated AIMP2 knockdown inhibited BRCA cell proliferation and migration in vitro. In conclusion, our pan-cancer analysis suggests that AIMP2 may play a crucial role in tumor immunity and could serve as a potential prognostic marker, particularly in BRCA.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Tipo de estudio: Prognostic_studies Idioma: En Revista: Curr Genomics Año: 2023 Tipo del documento: Article País de afiliación: China Pais de publicación: Emiratos Árabes Unidos
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Tipo de estudio: Prognostic_studies Idioma: En Revista: Curr Genomics Año: 2023 Tipo del documento: Article País de afiliación: China Pais de publicación: Emiratos Árabes Unidos