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Tissue adhesive, ROS scavenging and injectable PRP-based 'plasticine' for promoting cartilage repair.
Li, Shiao; Niu, Dawei; Fang, Haowei; Chen, Yancheng; Li, Jinyan; Zhang, Kunxi; Yin, Jingbo; Fu, Peiliang.
Afiliación
  • Li S; Department of Orthopedics, Shanghai Changzheng Hospital, Naval Medical University, Shanghai 200003, P.R. China.
  • Niu D; Department of Orthopedics, Shanghai Changzheng Hospital, Naval Medical University, Shanghai 200003, P.R. China.
  • Fang H; Department of Polymer Materials, School of Materials Science and Engineering, Shanghai University, Shanghai 200444, P.R. China.
  • Chen Y; Department of Orthopedics, Shanghai Changzheng Hospital, Naval Medical University, Shanghai 200003, P.R. China.
  • Li J; Department of Polymer Materials, School of Materials Science and Engineering, Shanghai University, Shanghai 200444, P.R. China.
  • Zhang K; Department of Polymer Materials, School of Materials Science and Engineering, Shanghai University, Shanghai 200444, P.R. China.
  • Yin J; Department of Polymer Materials, School of Materials Science and Engineering, Shanghai University, Shanghai 200444, P.R. China.
  • Fu P; Department of Orthopedics, Shanghai Changzheng Hospital, Naval Medical University, Shanghai 200003, P.R. China.
Regen Biomater ; 11: rbad104, 2024.
Article en En | MEDLINE | ID: mdl-38235061
ABSTRACT
Platelet-rich plasma (PRP) that has various growth factors has been used clinically in cartilage repair. However, the short residence time and release time at the injury site limit its therapeutic effect. The present study fabricated a granular hydrogel that was assembled from gelatin microspheres and tannic acid through their abundant hydrogen bonding. Gelatin microspheres with the gelatin concentration of 10 wt% and the diameter distribution of 1-10 µm were used to assemble by tannic acid to form the granular hydrogel, which exhibited elasticity under low shear strain, but flowability under higher shear strain. The viscosity decreased with the increase in shear rate. Meanwhile, the granular hydrogel exhibited self-healing feature during rheology test. Thus, granular hydrogel carrying PRP not only exhibited well-performed injectability but also performed like a 'plasticine' that possessed good plasticity. The granular hydrogel showed tissue adhesion ability and reactive oxygen species scavenging ability. Granular hydrogel carrying PRP transplanted to full-thickness articular cartilage defects could integrate well with native cartilage, resulting in newly formed cartilage articular fully filled in defects and well-integrated with the native cartilage and subchondral bone. The unique features of the present granular hydrogel, including injectability, plasticity, porous structure, tissue adhesion and reactive oxygen species scavenging provided an ideal PRP carrier toward cartilage tissue engineering.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Regen Biomater Año: 2024 Tipo del documento: Article Pais de publicación: Reino Unido
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Regen Biomater Año: 2024 Tipo del documento: Article Pais de publicación: Reino Unido