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Tackling the implementation gap for the uptake of NGS and advanced molecular diagnostics into healthcare systems.
Horgan, Denis; Van den Bulcke, Marc; Malapelle, Umberto; Troncone, Giancarlo; Normanno, Nicola; Capoluongo, Ettore D; Prelaj, Arsela; Rizzari, Carmelo; Trapani, Dario; Singh, Jaya; Kozaric, Marta; Longshore, John; Ottaviano, Manuel; Boccia, Stefania; Pravettoni, Gabriella; Cattaneo, Ivana; Malats, Núria; Buettner, Reinhard; Lekadir, Karim; de Lorenzo, Francesco; Hofman, Paul; De Maria, Ruggero.
Afiliación
  • Horgan D; European Alliance for Personalised Medicine, Brussels, Belgium.
  • Van den Bulcke M; Department of Molecular and Cellular Engineering, Jacob Institute of Biotechnology and Bioengineering, Faculty of Engineering and Technology, Sam Higginbottom University of Agriculture, Technology and Sciences, Prayagraj - 211007, Uttar Pradesh India.
  • Malapelle U; Belgian Cancer Centre, Sciensano, Brussels, Belgium.
  • Troncone G; Department of Public Health, University Federico II of Naples, 80131 Naples, Italy.
  • Normanno N; Department of Public Health, University Federico II of Naples, 80131 Naples, Italy.
  • Capoluongo ED; Istituto Nazionale Tumori "Fondazione G. Pascale" - IRCCS, Naples, Italy.
  • Prelaj A; Department of Molecular Medicine and Medical Biotechnologies, University of Naples Federico II, Naples, Italy.
  • Rizzari C; Department of Clinical Pathology and Genomics, Azienda Ospedaliera Per L'Emergenza Cannizzaro, Catania, Italy.
  • Trapani D; Department of Medical Oncology, Fondazione IRCCS Istituto Nazionale Tumori, Milan, Italy.
  • Singh J; Unità di Ematologia Pediatrica, Fondazione MBBM, Università di Milano-Bicocca, Monza, Italy.
  • Kozaric M; European Institute of Oncology, IRCCS, 20141 Milan, Italy.
  • Longshore J; European Alliance for Personalised Medicine, Brussels, Belgium.
  • Ottaviano M; European Alliance for Personalised Medicine, Brussels, Belgium.
  • Boccia S; Astra Zeneca, 1800 Concord Pike, Wilmington, DE 19803, USA.
  • Pravettoni G; Departamento de Tecnología Fotónica y Bioingeniería, Universidad Politècnica de Madrid, 28040 Madrid, Spain.
  • Cattaneo I; Section of Hygiene, Department of Life Sciences and Public Health, Università Cattolica del Sacro Cuore, Rome, Italy.
  • Malats N; Departments of Woman and Child Health and Public Health, Fondazione Policlinico Universitario A. Gemelli IRCCS, Rome, Italy.
  • Buettner R; Department of Oncology and Hemato-Oncology, University of Milan, Milan, Italy.
  • Lekadir K; Applied Research Division for Cognitive and Psychological Science, European Institute of Oncology (IEO) IRCCS, Milan, Italy.
  • de Lorenzo F; Novartis Farma SpA, 21040 Origgio, Italy.
  • Hofman P; Genetic and Molecular Epidemiology Group, Spanish National Cancer Research Centre (CNIO), Madrid 28029, Spain.
  • De Maria R; Lung Cancer Group Cologne, Institute of Pathology, Center for Integrated Oncology Cologne/Bonn, University Hospital Cologne, Cologne, Germany.
Heliyon ; 10(1): e23914, 2024 Jan 15.
Article en En | MEDLINE | ID: mdl-38234913
ABSTRACT
Next-generation sequencing (NGS) and liquid biopsy (LB) showed positive results in the fight against different cancer types. This paper aims to assess the uptake of advanced molecular diagnostics/NGS for quick and efficient genetic profiles of tumour cells. For that purpose, the European Alliance for Personalised Medicine conducted a series of expert interviews to ascertain the current status across member states. One stakeholder meeting was additionally conducted to prioritize relevant factors by stakeholders. Seven common pillars were identified, and twenty-five measures were defined based on these pillars. Results showed that a multi-faceted approach is necessary for successful NGS implementation and that regional differences may be influenced by healthcare policies, resources, and infrastructure. It is important to consider different correlations when interpreting the results and to use them as a starting point for further discussion.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Tipo de estudio: Diagnostic_studies / Prognostic_studies Aspecto: Implementation_research Idioma: En Revista: Heliyon Año: 2024 Tipo del documento: Article País de afiliación: Bélgica Pais de publicación: Reino Unido
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Tipo de estudio: Diagnostic_studies / Prognostic_studies Aspecto: Implementation_research Idioma: En Revista: Heliyon Año: 2024 Tipo del documento: Article País de afiliación: Bélgica Pais de publicación: Reino Unido