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Pre-emptive treatment of heart failure exacerbations in patients managed with the HeartLogic™ algorithm.
Garcia, Rodrigue; Gras, Daniel; Mansourati, Jacques; Defaye, Pascal; Bisson, Arnaud; Boveda, Serge; Gandjbakhch, Estelle; Gras, Matthieu; Gueffet, Jean-Pierre; Himbert, Caroline; Jacon, Peggy; Khattar, Pierre; Lequeux, Benoit; Li, Anthony; Mansourati, Vincent; Minois, Damien; Marijon, Eloi; Pierre, Bertrand; Probst, Vincent; Degand, Bruno.
Afiliación
  • Garcia R; Department of Cardiology, University Hospital of Poitiers, Poitiers, France.
  • Gras D; Centre d'investigation clinique 1402, University Hospital of Poitiers, Poitiers, France.
  • Mansourati J; Department of Cardiology, Hôpital privé du Confluent, Nantes, France.
  • Defaye P; Department of Cardiology, University Hospital of Brest, Brest, France.
  • Bisson A; Department of Cardiology, University Hospital Grenoble Alpes, Grenoble, France.
  • Boveda S; Department of Cardiology, University Hospital of Tours, Chambray-lès-Tours, France.
  • Gandjbakhch E; Department of Cardiology, University Hospital of Orléans, Orléans, France.
  • Gras M; Department of Cardiology, Clinique Pasteur, Toulouse, France.
  • Gueffet JP; Universiteit Ziekenhuis, Vrije Universiteit Brussel (VUB), Jette, Belgium.
  • Himbert C; Department of Cardiology, Hôpital la Pitié Salpétrière, Paris, France.
  • Jacon P; Department of Cardiology, University Hospital of Poitiers, Poitiers, France.
  • Khattar P; Department of Cardiology, Hôpital privé du Confluent, Nantes, France.
  • Lequeux B; Department of Cardiology, Hôpital la Pitié Salpétrière, Paris, France.
  • Li A; Department of Cardiology, University Hospital Grenoble Alpes, Grenoble, France.
  • Mansourati V; Department of Cardiology, Hospital of Lorient, Lorient, France.
  • Minois D; Department of Cardiology, University Hospital of Poitiers, Poitiers, France.
  • Marijon E; Department of Cardiology, St. George's University of London, Cranmer Terrace, London, UK.
  • Pierre B; Department of Cardiology, University Hospital of Brest, Brest, France.
  • Probst V; Department of Cardiology, University Hospital of Nantes, Nantes Cedex 1, France.
  • Degand B; Department of Cardiology, Hôpital Européen Georges Pomipdou, Paris, France.
ESC Heart Fail ; 11(2): 1228-1235, 2024 Apr.
Article en En | MEDLINE | ID: mdl-38234123
ABSTRACT

AIMS:

Heart failure (HF) is a chronic disease affecting 64 million people worldwide and places a severe burden on society because of its mortality, numerous re-hospitalizations and associated costs. HeartLogic™ is an algorithm programmed into implanted devices incorporating several biometric parameters which aims to predict HF episodes. It provides an index which can be monitored remotely, allowing pre-emptive treatment of congestion to prevent acute decompensation. We aim to assess the impact and security of pre-emptive HF management, guided by the HeartLogic™ index. METHODS AND

RESULTS:

The HeartLogic™ France Cohort Study is an investigator-initiated, prospective, multi-centre, non-randomized study. Three hundred ten patients with a history of HF (left ventricular ejection fraction ≤40%; or at least one episode of clinical HF with elevated NT-proBNP ≥450 ng/L) and implanted with a cardioverter defibrillator enabling HeartLogic™ index calculation will be included across 10 French centres. The HeartLogic™ index will be monitored remotely for 12 months and in the event of a HeartLogic™ index ≥16, the local investigator will contact the patient for assessment and adjust HF treatment as necessary. The primary endpoint is unscheduled hospitalization for HF. Secondary endpoints are all-cause mortality, cardiovascular death, HF-related death, unscheduled hospitalizations for ventricular or atrial arrhythmia and HeartLogic™ index evolution over time. Blood samples will be collected for biobanking, and quality of life will be assessed. Finally, the safety of a HeartLogic™-triggered strategy for initiating or increasing diuretic therapy will be assessed. A blind and independent committee will adjudicate the events.

CONCLUSIONS:

The HeartLogic™ France Cohort Study will provide robust real-world data in a cohort of HF patients managed with the HeartLogic™ algorithm allowing pre-emptive treatment of heart failure exacerbations.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Calidad de Vida / Insuficiencia Cardíaca Tipo de estudio: Clinical_trials / Observational_studies / Prognostic_studies / Risk_factors_studies Aspecto: Patient_preference Límite: Humans Idioma: En Revista: ESC Heart Fail Año: 2024 Tipo del documento: Article País de afiliación: Francia Pais de publicación: Reino Unido
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Calidad de Vida / Insuficiencia Cardíaca Tipo de estudio: Clinical_trials / Observational_studies / Prognostic_studies / Risk_factors_studies Aspecto: Patient_preference Límite: Humans Idioma: En Revista: ESC Heart Fail Año: 2024 Tipo del documento: Article País de afiliación: Francia Pais de publicación: Reino Unido