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Fc-fused IL-7 provides broad antiviral effects against respiratory virus infections through IL-17A-producing pulmonary innate-like T cells.
Kwon, Dong-Il; Park, Subin; Jeong, Yujin L; Kim, Young-Min; Min, Jeongyong; Lee, Changhyung; Choi, Jung-Ah; Choi, Yoon Ha; Kong, Hyun-Jung; Choi, Youngwon; Baek, Seungtae; Lee, Kun-Joo; Kang, Yeon-Woo; Jeong, Chaerim; You, Gihoon; Oh, Youngsik; Im, Sun-Kyoung; Song, Manki; Kim, Jong Kyoung; Chang, Jun; Choi, Donghoon; Lee, Seung-Woo.
Afiliación
  • Kwon DI; Department of Life Sciences, Pohang University of Science and Technology, Pohang 37666, Republic of Korea.
  • Park S; Department of Life Sciences, Pohang University of Science and Technology, Pohang 37666, Republic of Korea.
  • Jeong YL; Department of Life Sciences, Pohang University of Science and Technology, Pohang 37666, Republic of Korea.
  • Kim YM; Department of Life Sciences, Pohang University of Science and Technology, Pohang 37666, Republic of Korea.
  • Min J; Department of Life Sciences, Pohang University of Science and Technology, Pohang 37666, Republic of Korea.
  • Lee C; Department of Life Sciences, Pohang University of Science and Technology, Pohang 37666, Republic of Korea.
  • Choi JA; Science Unit, International Vaccine Institute, Seoul 08826, Republic of Korea.
  • Choi YH; Department of Life Sciences, Pohang University of Science and Technology, Pohang 37666, Republic of Korea.
  • Kong HJ; Graduate School of Pharmaceutical Sciences, Ewha Womans University, Seoul 03760, Republic of Korea.
  • Choi Y; Graduate School of Pharmaceutical Sciences, Ewha Womans University, Seoul 03760, Republic of Korea.
  • Baek S; Research Institute of NeoImmuneTech Co., Ltd., Pohang 37666, Republic of Korea.
  • Lee KJ; Department of Life Sciences, Pohang University of Science and Technology, Pohang 37666, Republic of Korea.
  • Kang YW; Department of Life Sciences, Pohang University of Science and Technology, Pohang 37666, Republic of Korea.
  • Jeong C; Department of Life Sciences, Pohang University of Science and Technology, Pohang 37666, Republic of Korea.
  • You G; Department of Life Sciences, Pohang University of Science and Technology, Pohang 37666, Republic of Korea.
  • Oh Y; Department of Life Sciences, Pohang University of Science and Technology, Pohang 37666, Republic of Korea.
  • Im SK; Research Institute of NeoImmuneTech Co., Ltd., Pohang 37666, Republic of Korea.
  • Song M; Science Unit, International Vaccine Institute, Seoul 08826, Republic of Korea.
  • Kim JK; Department of Life Sciences, Pohang University of Science and Technology, Pohang 37666, Republic of Korea.
  • Chang J; Graduate School of Pharmaceutical Sciences, Ewha Womans University, Seoul 03760, Republic of Korea.
  • Choi D; Research Institute of NeoImmuneTech Co., Ltd., Pohang 37666, Republic of Korea. Electronic address: dhchoi@neoimmunetech.com.
  • Lee SW; Department of Life Sciences, Pohang University of Science and Technology, Pohang 37666, Republic of Korea. Electronic address: sw_lee@postech.ac.kr.
Cell Rep Med ; 5(1): 101362, 2024 01 16.
Article en En | MEDLINE | ID: mdl-38232693
ABSTRACT
Repeated pandemics caused by the influenza virus and severe acute respiratory syndrome coronavirus (SARS-CoV) have resulted in serious problems in global public health, emphasizing the need for broad-spectrum antiviral therapeutics against respiratory virus infections. Here, we show the protective effects of long-acting recombinant human interleukin-7 fused with hybrid Fc (rhIL-7-hyFc) against major respiratory viruses, including influenza virus, SARS-CoV-2, and respiratory syncytial virus. Administration of rhIL-7-hyFc in a therapeutic or prophylactic regimen induces substantial antiviral effects. During an influenza A virus (IAV) infection, rhIL-7-hyFc treatment increases pulmonary T cells composed of blood-derived interferon γ (IFNγ)+ conventional T cells and locally expanded IL-17A+ innate-like T cells. Single-cell RNA transcriptomics reveals that rhIL-7-hyFc upregulates antiviral genes in pulmonary T cells and induces clonal expansion of type 17 innate-like T cells. rhIL-7-hyFc-mediated disease prevention is dependent on IL-17A in both IAV- and SARS-CoV-2-infected mice. Collectively, we suggest that rhIL-7-hyFc can be used as a broadly active therapeutic for future respiratory virus pandemic.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Interleucina-17 / Gripe Humana Límite: Animals / Humans Idioma: En Revista: Cell Rep Med Año: 2024 Tipo del documento: Article Pais de publicación: Estados Unidos
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Interleucina-17 / Gripe Humana Límite: Animals / Humans Idioma: En Revista: Cell Rep Med Año: 2024 Tipo del documento: Article Pais de publicación: Estados Unidos