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Task-related brain activity in upper limb dystonia revealed by simultaneous fNIRS and EEG.
Marques Paulo, Artur José; Sato, João Ricardo; de Faria, Danilo Donizete; Balardin, Joana; Borges, Vanderci; de Azevedo Silva, Sonia Maria; Ballalai Ferraz, Henrique; de Carvalho Aguiar, Patrícia.
Afiliación
  • Marques Paulo AJ; Hospital Israelita Albert Einstein, Instituto de Ensino e Pesquisa, Av. Albert Einstein, 627, São Paulo-SP 05652-900, Brazil.
  • Sato JR; Hospital Israelita Albert Einstein, Instituto de Ensino e Pesquisa, Av. Albert Einstein, 627, São Paulo-SP 05652-900, Brazil; Universidade Federal do ABC, Centro de Matemática Computação e Cognição , São Bernardo do Campo-SP , 09606-045, Brazil.
  • de Faria DD; Universidade Federal de São Paulo, Department of Neurology and Neurosurgery, R. Pedro de Toledo, 650, São Paulo - SP 04039-002, Brazil; Hospital do Servidor Público Estadual, Av. Ibirapuera, 981 - Vila Clementino, São Paulo - SP 04038-034, Brazil.
  • Balardin J; Hospital Israelita Albert Einstein, Instituto de Ensino e Pesquisa, Av. Albert Einstein, 627, São Paulo-SP 05652-900, Brazil.
  • Borges V; Universidade Federal de São Paulo, Department of Neurology and Neurosurgery, R. Pedro de Toledo, 650, São Paulo - SP 04039-002, Brazil.
  • de Azevedo Silva SM; Universidade Federal de São Paulo, Department of Neurology and Neurosurgery, R. Pedro de Toledo, 650, São Paulo - SP 04039-002, Brazil; Hospital do Servidor Público Estadual, Av. Ibirapuera, 981 - Vila Clementino, São Paulo - SP 04038-034, Brazil.
  • Ballalai Ferraz H; Universidade Federal de São Paulo, Department of Neurology and Neurosurgery, R. Pedro de Toledo, 650, São Paulo - SP 04039-002, Brazil.
  • de Carvalho Aguiar P; Hospital Israelita Albert Einstein, Instituto de Ensino e Pesquisa, Av. Albert Einstein, 627, São Paulo-SP 05652-900, Brazil; Universidade Federal de São Paulo, Department of Neurology and Neurosurgery, R. Pedro de Toledo, 650, São Paulo - SP 04039-002, Brazil. Electronic address: patmcaguiar@gmail.
Clin Neurophysiol ; 159: 1-12, 2024 03.
Article en En | MEDLINE | ID: mdl-38232654
ABSTRACT

OBJECTIVE:

The aim of this study was to explore differences in brain activity and connectivity using simultaneous electroencephalography and near-infrared spectroscopy in patients with focal dystonia during handwriting and finger-tapping tasks.

METHODS:

Patients with idiopathic right upper limb focal dystonia and controls were assessed by simultaneous near-infrared spectroscopy and electroencephalography during the writing and finger-tapping tasks in terms of the mu-alpha, mu-beta, beta and low gamma power and effective connectivity, as well as relative changes in oxyhemoglobin (oxy-Hb) and deoxyhemoglobin using a channel-wise approach with a mixed-effect model.

RESULTS:

Patients exhibited higher oxy-Hb levels in the right and left motor cortex and supplementary motor area during writing, but lower oxy-Hb levels in the left sensorimotor and bilateral somatosensory area during finger-tapping compared to controls. During writing, patients showed increased low gamma power in the bilateral sensorimotor cortex and less mu-beta and beta attenuation compared to controls. Additionally, patients had reduced connectivity between the supplementary motor area and the left sensorimotor cortex during writing. No differences were observed in terms of effective connectivity in either task. Finally, patients failed to attenuate the mu-alpha, mu-beta, and beta rhythms during the finger-tapping task.

CONCLUSIONS:

Cortical blood flow and EEG spectral power differ between controls and dystonia patients, depending on the task. Writing increased blood flow and altered connectivity in dystonia patients, and it also decreased slow-band attenuation. Finger-tapping decreased blood flow and slow-band attenuation.

SIGNIFICANCE:

Simultaneous fNIRS and EEG may show relevant information regarding brain dynamics in movement disorders patients in unconstrained environments.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Trastornos Distónicos / Distonía / Corteza Sensoriomotora / Corteza Motora Límite: Humans Idioma: En Revista: Clin Neurophysiol Asunto de la revista: NEUROLOGIA / PSICOFISIOLOGIA Año: 2024 Tipo del documento: Article País de afiliación: Brasil Pais de publicación: Países Bajos
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Trastornos Distónicos / Distonía / Corteza Sensoriomotora / Corteza Motora Límite: Humans Idioma: En Revista: Clin Neurophysiol Asunto de la revista: NEUROLOGIA / PSICOFISIOLOGIA Año: 2024 Tipo del documento: Article País de afiliación: Brasil Pais de publicación: Países Bajos