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Insights on Protective Effect of Platelet Rich Plasma and Tadalafil on Testicular Ischemia/Reperfusion Injury in Rats Exposed to Testicular Torsion/Detorsion.
Abdel Ghaffar, Dalia M; Eldken, Zienab Helmy; Sultan, Mohammed S; Khalil, Rania M; Sakr, Noha Hamma; Eissa, Hanan; Safwat, Sally M.
Afiliación
  • Abdel Ghaffar DM; Department of Medical Physiology, Faculty of Medicine, Mansoura University, Mansoura 35516, Egypt.
  • Eldken ZH; Department of Physiology, Faculty of Medicine, Mansoura University, Mansoura, Egypt.
  • Sultan MS; Department of Basic Medical Sciences, Ibn Sina University for Medical Sciences, Amman 11104, Jordan.
  • Khalil RM; Department of Dermatology, Andrology and STDs, Faculty of Medicine, Mansoura University, Mansoura, Egypt.
  • Sakr NH; Department of Biochemistry, Faculty of Pharmacy, Delta University for Science and Technology, Gamasa, Egypt. rania742002@yahoo.com; Rania.khalil@deltauniv.edu.eg.
  • Eissa H; Department of Anatomy and embryology, Faculty of Medicine, Kafrelsheikh University, Kafrelsheikh, Egypt.
  • Safwat SM; Department of Clinical Pharmacology, Faculty of Medicine, Mansoura University, Mansoura, Egypt.
Cell Physiol Biochem ; 58(1): 14-32, 2024 01 16.
Article en En | MEDLINE | ID: mdl-38232236
ABSTRACT
BACKGROUND/

AIMS:

Ischemic reperfusion (I-R) injury is greatly influenced by the testicular torsion/detorsion process (TDP). In this instance, the anti-inflammatory properties of plateletrich plasma (PRP) combined with tadalafil (Td) significantly promote tissue healing in the I-R injury model.

METHODS:

Five groups of rats were created the control group, the I-R group not receiving any therapy, the I-R group receiving a single dosage of Td (0.25 mg/kg, I.P.), the I-R group receiving a single dose of PRP (80 l, intratesticular), and the I-R group receiving both Td and PRP. Sperm morphology, motility, and histology were assessed. The levels of TNF-, BAX, antioxidant status, and testosterone were measured. Additionally, E-selectin expression was done.

RESULTS:

PRP reduced oxidative stress, inflammation, and apoptosis while also boosting testosterone levels, which alleviated I-R injury. Otherwise, PRP reduces E-selectin expression, which modifies the pathways that control endothelial function. Td also partially demonstrated its testicular-protective activity at the same time.

CONCLUSION:

PRP's proven anti-inflammatory, antioxidant, and antiapoptotic potentials make it a natural treatment for testicular harm caused by tadalafil. For the first time, it was demonstrated that PRP therapy restored the functionality of the vascular endothelium, specifically the control of E-selectin expression. Combining Td and PRP therapy may be a promising strategy for improving response to PDE5 inhibitors.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Torsión del Cordón Espermático / Daño por Reperfusión / Plasma Rico en Plaquetas Tipo de estudio: Etiology_studies Límite: Animals / Humans / Male Idioma: En Revista: Cell Physiol Biochem Asunto de la revista: BIOQUIMICA / FARMACOLOGIA Año: 2024 Tipo del documento: Article País de afiliación: Egipto Pais de publicación: Alemania
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Torsión del Cordón Espermático / Daño por Reperfusión / Plasma Rico en Plaquetas Tipo de estudio: Etiology_studies Límite: Animals / Humans / Male Idioma: En Revista: Cell Physiol Biochem Asunto de la revista: BIOQUIMICA / FARMACOLOGIA Año: 2024 Tipo del documento: Article País de afiliación: Egipto Pais de publicación: Alemania