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Choice of surgery in intestinal-type adenocarcinoma of the sinonasal tract: a long-term comparative study.
Vermassen, Tijl; De Keukeleire, Stijn; Saerens, Michael; Heerwegh, Sylvester; Debacker, Jens M; Huvenne, Wouter; Deron, Philippe; Creytens, David; Ferdinande, Liesbeth; Rottey, Sylvie; Bachert, Claus; Duprez, Fréderic; Van Zele, Thibaut.
Afiliación
  • Vermassen T; Department Medical Oncology, University Hospital Ghent, Corneel Heymanslaan 10, Ghent, Belgium. tijl.vermassen@uzgent.be.
  • De Keukeleire S; Biomarkers in Cancer, Ghent University, Ghent, Belgium. tijl.vermassen@uzgent.be.
  • Saerens M; Cancer Research Institute Ghent, Ghent, Belgium. tijl.vermassen@uzgent.be.
  • Heerwegh S; Department Internal Medicine, University Hospital Brussels, Brussels, Belgium.
  • Debacker JM; Department Medical Oncology, University Hospital Ghent, Corneel Heymanslaan 10, Ghent, Belgium.
  • Huvenne W; Biomarkers in Cancer, Ghent University, Ghent, Belgium.
  • Deron P; Cancer Research Institute Ghent, Ghent, Belgium.
  • Creytens D; Department Medical Oncology, University Hospital Ghent, Corneel Heymanslaan 10, Ghent, Belgium.
  • Ferdinande L; Cancer Research Institute Ghent, Ghent, Belgium.
  • Rottey S; Laboratory for Molecular Imaging and Therapy, Vrije Universiteit Brussel, Brussels, Belgium.
  • Bachert C; Department Head and Neck Surgery, University Hospital Ghent, Ghent, Belgium.
  • Duprez F; Cancer Research Institute Ghent, Ghent, Belgium.
  • Van Zele T; Department Head and Neck Surgery, University Hospital Ghent, Ghent, Belgium.
Eur Arch Otorhinolaryngol ; 281(6): 2993-3004, 2024 Jun.
Article en En | MEDLINE | ID: mdl-38228884
ABSTRACT

PURPOSE:

Intestinal-type adenocarcinoma (ITAC) is a rare sinonasal malignancy. Curative treatment requires multidisciplinary approach, with surgical options consist of the endonasal endoscopic approach (EEA) and external surgery (EXTS). Here, we provide the post-operative and survival results from a single-center long-term follow-up.

METHODS:

We report long-term follow-up of 92 ITAC cases treated between 1998 and 2018, treated with EEA (n = 40) or EXTS (n = 52). Survival estimates, post-operative complications and duration of hospitalization were compared between surgical modalities.

RESULTS:

Baseline characteristics were similar. A higher number of T4b tumors (16%), and subsequently more tumoral invasion (39%), was present in patients undergoing EXTS compared to EEA (3% and 18%, respectively). No difference in Barnes histology subtypes was noticed. Patients undergoing EEA had a shorter post-operative hospitalization stay versus EXTS (4 versus 7 days). Use of EEA was associated to improved disease-specific survival (DSS; 11.4 versus 4.4 years; HREEA = 0.53), especially for patients with T3-4a tumors (11.4 versus 3.0 years; HREEA = 0.41). Patients with T3-4 stage, tumoral invasion, positive surgical margins, mucinous or mixed histology, and prolonged post-operative hospital stay showed poor local relapse-free, disease-free, overall, and DSS.

CONCLUSIONS:

Long-term follow-up in locally advanced ITAC demonstrates that resection by EEA is correlated with improved DSS compared to EXTS, especially for T3-4 tumors. No significant differences between both treatment modalities was observed regarding per- and post-operative complications, although hospitalization in patients undergoing EEA was shorter than for patients treated with EXTS. These results confirm that EEA should remain the preferred surgical procedure in operable cases of sinonasal ITAC.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Neoplasias de los Senos Paranasales / Adenocarcinoma Tipo de estudio: Prognostic_studies Límite: Adult / Aged / Female / Humans / Male / Middle aged Idioma: En Revista: Eur Arch Otorhinolaryngol Asunto de la revista: OTORRINOLARINGOLOGIA Año: 2024 Tipo del documento: Article País de afiliación: Bélgica Pais de publicación: Alemania
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Neoplasias de los Senos Paranasales / Adenocarcinoma Tipo de estudio: Prognostic_studies Límite: Adult / Aged / Female / Humans / Male / Middle aged Idioma: En Revista: Eur Arch Otorhinolaryngol Asunto de la revista: OTORRINOLARINGOLOGIA Año: 2024 Tipo del documento: Article País de afiliación: Bélgica Pais de publicación: Alemania