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Choline kinase alpha genotype is related to hippocampal brain volume and cognition in postmenopausal women.
Myers, Abigail J; Potts, Callum; Makarewicz, Jenna A; McGee, Elizabeth; Dumas, Julie A.
Afiliación
  • Myers AJ; Department of Psychiatry, Larner College of Medicine, University of Vermont, USA.
  • Potts C; Department of Obstetrics, Gynecology, and Reproductive Sciences, Larner College of Medicine, University of Vermont, USA.
  • Makarewicz JA; Department of Psychiatry, Larner College of Medicine, University of Vermont, USA.
  • McGee E; Department of Obstetrics, Gynecology, and Reproductive Sciences, Larner College of Medicine, University of Vermont, USA.
  • Dumas JA; Department of Psychiatry, Larner College of Medicine, University of Vermont, USA.
Heliyon ; 10(1): e23963, 2024 Jan 15.
Article en En | MEDLINE | ID: mdl-38226229
ABSTRACT
This study examined how single nucleotide polymorphisms (SNPs) related to choline synthesis and metabolism, processes largely regulated by estrogen, influenced hippocampal volume and neuropsychological function following menopause. We investigated the effect of choline kinase alpha (CHKA) genotype on brain volume and neuropsychological performance in postmenopausal women. The effect alleles of certain CHKA SNPs (rs6591331 T, rs10791957 A) are associated with varied responses to choline deficiency and delegation of choline to physiological pathways. The presence of these alleles was hypothesized to correlate with worse cognitive performance in women after menopause. Results from structural MRI scans revealed larger right hippocampal volumes in subjects with a T/T CHKA rs6591331 genotype compared to A/A subjects. Delayed memory scores from the Repeatable Battery for the Assessment of Neuropsychological Status (RBANS) were lower in subjects with T/T genotypes compared to those with the A/T genotype and the A/A genotype. Based on these findings, we proposed a CHKA-dependent mechanism present within the brain to compensate for the decreased estrogen and biosynthesized choline associated with menopause.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Heliyon Año: 2024 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Reino Unido
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Heliyon Año: 2024 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Reino Unido