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Distinct parallel activation and interaction between dorsal and ventral pathways during phonological and semantic processing: A cTBS-fMRI study.
Luo, Yudan; Wang, Ke; Jiao, Saiyi; Zeng, Jiahong; Han, Zaizhu.
Afiliación
  • Luo Y; National Key Laboratory of Cognitive Neuroscience and Learning and IDG/McGovern Institute for Brain Research, Beijing Normal University, Beijing, China.
  • Wang K; National Key Laboratory of Cognitive Neuroscience and Learning and IDG/McGovern Institute for Brain Research, Beijing Normal University, Beijing, China.
  • Jiao S; School of System Science, Beijing Normal University, Beijing, China.
  • Zeng J; National Key Laboratory of Cognitive Neuroscience and Learning and IDG/McGovern Institute for Brain Research, Beijing Normal University, Beijing, China.
  • Han Z; National Key Laboratory of Cognitive Neuroscience and Learning and IDG/McGovern Institute for Brain Research, Beijing Normal University, Beijing, China.
Hum Brain Mapp ; 45(1): e26569, 2024 Jan.
Article en En | MEDLINE | ID: mdl-38224540
ABSTRACT
Successful visual word recognition requires the integration of phonological and semantic information, which is supported by the dorsal and ventral pathways in the brain. However, the functional specialization or interaction of these pathways during phonological and semantic processing remains unclear. Previous research has been limited by its dependence on correlational functional magnetic resonance imaging (fMRI) results or causal validation using patient populations, which are susceptible to confounds such as plasticity and lesion characteristics. To address this, the present study employed continuous theta-burst stimulation combined with fMRI in a within-subject design to assess rapid adaptation in regional activity and functional connectivity of the dorsal and ventral pathways during phonological and semantic tasks. This assessment followed the precise inhibition of the left inferior parietal lobule and anterior temporal lobe in the dorsal and ventral pathways, respectively. Our results reveal that both the dorsal and ventral pathways were activated during phonological and semantic processing, while the adaptation activation and interactive network were modulated by the task type and inhibited region. The two pathways exhibited interconnectivity in phonological processing, and disruption of either pathway led to rapid adaptation across both pathways. In contrast, only the ventral pathway exhibited connectivity in semantic processing, and disruption of this pathway alone resulted in adaptive effects primarily in the ventral pathway. These findings provide essential evidence supporting the interactive theory, phonological information processing in particular, potentially providing meaningful implications for clinical populations.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Semántica / Imagen por Resonancia Magnética Límite: Humans Idioma: En Revista: Hum Brain Mapp Asunto de la revista: CEREBRO Año: 2024 Tipo del documento: Article País de afiliación: China Pais de publicación: Estados Unidos
Texto completo
Añadir a Mi BVS
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XML
PubMed Links
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Semántica / Imagen por Resonancia Magnética Límite: Humans Idioma: En Revista: Hum Brain Mapp Asunto de la revista: CEREBRO Año: 2024 Tipo del documento: Article País de afiliación: China Pais de publicación: Estados Unidos