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Vitamin D levels and lipid profile in children and adolescents: a tight correlation.
Ceruti, Daniele; Colombo, Carla; Loiodice, Martina; DE Leo, Simone; Calcaterra, Valeria; Fabiano, Valentina.
Afiliación
  • Ceruti D; Department of Medical Biotechnology and Translational Medicine, University of Milan, Milan, Italy.
  • Colombo C; Department of Pathophysiology and Transplantation, University of Milan, Milan, Italy - carla.colombo1@unimi.it.
  • Loiodice M; Division of Endocrine and Metabolic Diseases, Istituto Auxologico IRCCS, Milan, Italy.
  • DE Leo S; Department of Pediatrics, Vittore Buzzi Children's Hospital, Milan, Italy.
  • Calcaterra V; Division of Endocrine and Metabolic Diseases, Istituto Auxologico IRCCS, Milan, Italy.
  • Fabiano V; Department of Pediatrics, Vittore Buzzi Children's Hospital, Milan, Italy.
Minerva Pediatr (Torino) ; 2024 Jan 15.
Article en En | MEDLINE | ID: mdl-38224323
ABSTRACT

INTRODUCTION:

Vitamin D is an essential hormone for humans, playing an important role in musculoskeletal and calcium homeostasis. Its deficiency/insufficiency seems to contribute to the development of cardiometabolic diseases in adults this correlation appears less clear for children and adolescents. The aim of this paper was to review literature data on the relationship between vitamin D and lipid profile alterations in pediatric population. EVIDENCE ACQUISITION We carried out a comprehensive research in electronic databases, including MEDLINE and PubMed up to December 2022, for cross-sectional or prospective studies that investigated the correlation between serum vitamin D levels and lipid profile in children and adolescents. At the end of the process, 37 articles were included in this review. EVIDENCE

SYNTHESIS:

According to our findings, vitamin D deficiency/insufficiency is strongly associated with lower high-density lipoprotein (HDL) cholesterol levels and higher levels of triglycerides and total cholesterol. Data about low-density lipoproteins (LDL) cholesterol are inconsistent. The potential role of vitamin D supplements for the prevention of cardiometabolic disease currently remains a speculation.

CONCLUSIONS:

An increasing number of studies shows how hypovitaminosis D in the pediatric age may play a role in the pathogenesis of metabolic disorders and lipid profile alterations. Data regarding the potential role of vitamin D supplements for the prevention of cardiometabolic disease are currently controversial. Further studies are needed to evaluate the causality of this association and to assess the underlying pathogenetic mechanisms.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Tipo de estudio: Observational_studies / Risk_factors_studies Idioma: En Revista: Minerva Pediatr (Torino) Año: 2024 Tipo del documento: Article País de afiliación: Italia Pais de publicación: Italia
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Tipo de estudio: Observational_studies / Risk_factors_studies Idioma: En Revista: Minerva Pediatr (Torino) Año: 2024 Tipo del documento: Article País de afiliación: Italia Pais de publicación: Italia