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Impact of maternal stress on metabolism and penile morphology in young offspring rats.
Macedo, Carolinne; Monnerat, Juliana; Lucchetti, Bianca; Teixeira, Gabriel; Mentzinger, Juliana; Rocha, Helena; Medeiros, Renata; Rocha, Natália; de Souza, Diogo; Sampaio, Francisco; Gregorio, Bianca.
Afiliación
  • Macedo C; Urogenital Research Unit, Biomedical Center, State University of Rio de Janeiro, Rio de Janeiro, Brazil.
  • Monnerat J; Federal Fluminense University, Exercise Science Laboratory (LACE), Niteroi, Brazil.
  • Lucchetti B; Federal Fluminense University, Exercise Science Laboratory (LACE), Niteroi, Brazil.
  • Teixeira G; Federal Fluminense University, Physiology and Pharmacology Department, Niteroi, Brazil.
  • Mentzinger J; Federal Fluminense University, Exercise Science Laboratory (LACE), Niteroi, Brazil.
  • Rocha H; Federal Fluminense University, Physiology and Pharmacology Department, Niteroi, Brazil.
  • Medeiros R; Federal Fluminense University, Exercise Science Laboratory (LACE), Niteroi, Brazil.
  • Rocha N; Federal Fluminense University, Physiology and Pharmacology Department, Niteroi, Brazil.
  • de Souza D; Urogenital Research Unit, Biomedical Center, State University of Rio de Janeiro, Rio de Janeiro, Brazil.
  • Sampaio F; Urogenital Research Unit, Biomedical Center, State University of Rio de Janeiro, Rio de Janeiro, Brazil.
  • Gregorio B; Urogenital Research Unit, Biomedical Center, State University of Rio de Janeiro, Rio de Janeiro, Brazil. biancamgregorio.uerj@gmail.com.
Histol Histopathol ; 39(8): 1009-1015, 2024 Aug.
Article en En | MEDLINE | ID: mdl-38221876
ABSTRACT
Exposure to prolonged stress in pregnancy and/or lactation can lead to the future development of diseases. We aimed to study the effects of maternal stress on the biometry, metabolism, and penile morphology of young Wistar rats. Animals were divided into two experimental groups Control Group (C) - pups from control mothers, without any intervention (n=5); and Chronic Stress Group (S) - pups from mothers who suffered variable stress in the third week of pregnancy (14th to 21st day; n=5). Food intake and body mass of the pups (n=10, in the C group and n=9 in the S group) were checked; at euthanasia (three months old), fat deposits and penis were removed. At birth and weaning, S animals were lighter than C animals, [-33.72% (p=0.0422) and -17.07% (p=0.0018)], respectively. However, the final body mass and body mass delta showed no differences. Food intake and fat deposits also did not differ. However, the S group was hyperglycemic at 30 and 60 days of life [+20.59% (p=0.0042) and +14.56% (p=0.0079), respectively], despite the glycemia measured at 90 days showing no difference between groups. Penile areas and surface densities of the corpora cavernosa components were similar between groups. The results indicate that maternal stress is an important metabolic programmer, which generates low birth weight and accelerated recovery of body mass after birth (catch-up). However, in an early analysis (90 days of life), exposure to gestational stress did not change the morphology of the offspring's penis in adulthood.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Pene / Efectos Tardíos de la Exposición Prenatal / Estrés Psicológico / Ratas Wistar Límite: Animals / Pregnancy Idioma: En Revista: Histol Histopathol Asunto de la revista: HISTOLOGIA / PATOLOGIA Año: 2024 Tipo del documento: Article País de afiliación: Brasil Pais de publicación: España
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Pene / Efectos Tardíos de la Exposición Prenatal / Estrés Psicológico / Ratas Wistar Límite: Animals / Pregnancy Idioma: En Revista: Histol Histopathol Asunto de la revista: HISTOLOGIA / PATOLOGIA Año: 2024 Tipo del documento: Article País de afiliación: Brasil Pais de publicación: España