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Effects of intermittent fasting regimens on glycemic, hepatic, anthropometric, and clinical markers in patients with non-alcoholic fatty liver disease: Systematic review and meta-analysis of randomized controlled trials.
Saleh, Saleh A K; Santos, Heitor O; Gaman, Mihnea-Alexandru; Cerqueira, Henrique S; Zaher, Eman Abbas; Alromaih, Wafa Romaih; Arafat, Norah Saud; Adi, Abdul Rahman; Adly, Heba M; Alyoubi, Reem; Alyahyawi, Naseem; Kord-Varkaneh, Hamed.
Afiliación
  • Saleh SAK; Department of Biochemistry, Faculty of Medicine, Umm Al-Qura University, Makkah, Saudi Arabia; Oncology Diagnostic Unit, Faculty of Medicine, Ain Shams University, Cairo, Egypt.
  • Santos HO; School of Medicine, Federal University of Uberlandia (UFU), Uberlandia 38408-100, Brazil.
  • Gaman MA; Faculty of Medicine, Carol Davila, University of Medicine and Pharmacy, Bucharest, Romania; Center of Hematology and Bone Marrow Transplantation, Fundeni Clinical Institute, Bucharest, Romania.
  • Cerqueira HS; School of Medicine, University of São Paulo (USP), Ribeirão Preto 14049-900, Brazil.
  • Zaher EA; Department of Family Medicine, King Abdulaziz Medical City, Riyadh, Saudi Arabia.
  • Alromaih WR; Department of Family Medicine, King Abdulaziz Medical City, Riyadh, Saudi Arabia.
  • Arafat NS; Department of Family Medicine, Security Forces Hospital, Riyadh, Saudi Arabia.
  • Adi AR; College of Medicine, Alfaisal University, Riyadh, Saudi Arabia.
  • Adly HM; Department of Community Medicine and Pilgrims Healthcare, Faculty of Medicine, Umm Al-Qura University, Makkah, Saudi Arabia.
  • Alyoubi R; Department of Pediatrics, King Abdulaziz University Hospital, Jeddah, Saudi Arabia.
  • Alyahyawi N; Department of Pediatrics, King Abdulaziz University Hospital, Jeddah, Saudi Arabia.
  • Kord-Varkaneh H; Department of Nutrition and Food Hygiene, Nutrition Health Research Center, Hamadan University of Medical Sciences, Hamadan, Iran. Electronic address: hamedkord39@yahoo.com.
Clin Nutr ESPEN ; 59: 70-80, 2024 02.
Article en En | MEDLINE | ID: mdl-38220409
ABSTRACT

OBJECTIVES:

Intermittent fasting (IF) regimens have been hypothesized to influence several markers of cardiometabolic and liver function. The objective of our meta-analysis was to investigate the impact of IF regimens on cardiometabolic and liver markers in subjects diagnosed with non-alcoholic fatty liver disease (NAFLD).

METHODS:

We searched several online databases (PubMed/Medline, Web of Science, Scopus and Embase) in order to identify suitable publications for inclusion in the meta-analysis. Results were expressed as weighted mean differences (WMD).

RESULTS:

From 12343 articles identified in different databases, a total of 7 RCT arms were entered into the quantitative synthesis. The manuscripts were published between 2019 and 2023. IF regimens (the 52 diet, 16/8 time-restricting feeding, and alternate day fasting) varied from 2 months to 3 months. IF regimens reduced steatosis scores (WMD -33.22 CAP dB/m, 95 % CI -50.72 to -15.72), anthropometric characteristics of obesity (WMD -0.77 kg/m2, 95 % CI -1.38 to -0.17 for body mass index; WMD -3.16 kg, 95 % CI -4.71 to -1.61 for body weight; WMD -1.90 kg, 95 % CI -3.51 to -0.29 for waist circumference), as well as ALT (WMD -9.10 U/L, 95 % CI -12.45 to -5.75), triglyceride (WMD -20.83 mg/dl, 95 % CI -39.01 to -2.66), total cholesterol (WMD -7.80 mg/dl, 95 % CI -15.18), HbA1c (WMD -0.14 %, 95 % CI -0.20 to -0.08) and HOMA-IR (WMD -1.21, 95 % CI -2.08 to -0.34) levels versus controls. Nevertheless, no between-group differences were detected for other biomarkers, e.g., fasting blood glucose, insulin, AST, HDL-C or LDL-C values, and fibrosis scores.

CONCLUSION:

IF regimens can improve some markers of cardiometabolic and liver function in patients with NAFLD. However, the available evidence to support the benefits of IF regimens is limited and derived from a small number of studies, thus further research is needed to clarify the impact of IF on the cardiometabolic health of NAFLD patients.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Enfermedades Cardiovasculares / Enfermedad del Hígado Graso no Alcohólico Tipo de estudio: Clinical_trials / Prognostic_studies / Systematic_reviews Límite: Humans Idioma: En Revista: Clin Nutr ESPEN Año: 2024 Tipo del documento: Article País de afiliación: Egipto Pais de publicación: Reino Unido
Texto completo
Añadir a Mi BVS
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XML
PubMed Links
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Enfermedades Cardiovasculares / Enfermedad del Hígado Graso no Alcohólico Tipo de estudio: Clinical_trials / Prognostic_studies / Systematic_reviews Límite: Humans Idioma: En Revista: Clin Nutr ESPEN Año: 2024 Tipo del documento: Article País de afiliación: Egipto Pais de publicación: Reino Unido