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The equine umbilical cord in clinically healthy pregnancies.
Lawson, Jessica M; Verheyen, Kristien; Smith, Ken C; Bryan, Jill S; Foote, Alastair K; de Mestre, Amanda M.
Afiliación
  • Lawson JM; Pathobiology and Population Sciences, Royal Veterinary College, Hertfordshire, UK.
  • Verheyen K; Comparative Biomedical Sciences, Royal Veterinary College, Hertfordshire, UK.
  • Smith KC; Pathobiology and Population Sciences, Royal Veterinary College, Hertfordshire, UK.
  • Bryan JS; Pathobiology and Population Sciences, Royal Veterinary College, Hertfordshire, UK.
  • Foote AK; Rossdales Laboratories, Suffolk, UK.
  • de Mestre AM; Rossdales Laboratories, Suffolk, UK.
Equine Vet J ; 56(4): 742-750, 2024 Jul.
Article en En | MEDLINE | ID: mdl-38219774
ABSTRACT

BACKGROUND:

Excessive umbilical cord length (UCL) is associated with equine pregnancy loss. However, a lack of UCL reference values makes it difficult to define excessive UCL. Further, factors associated with differences in UCL are poorly understood.

OBJECTIVES:

To (i) report the total, allantoic and amniotic UCL in healthy term pregnancies in Thoroughbreds, (ii) describe the relationship between gestational age and UCL, fetal weight and crown rump length (CRL) using clinically normal pregnancies (CNPs) from mares dying during gestation, and (iii) identify associations between UCL and maternal age and parity, paternal age, and fetal sex. STUDY

DESIGN:

Cross-sectional.

METHODS:

Data including UCLs, fetal weight, CRL and maternal age, parity, paternal age and fetal sex were taken from CNPs from Thoroughbred mares dying during gestation (n = 32), and placentas from HTPs (n = 34) in England. Correlations were assessed using Spearman's rank with significant correlations estimated by locally weighted scatter plot smoothing (LOWESS). Regression plots were fitted to highly correlated variables to further assess and quantify relationships. Differences in UCL between categorical variables were assessed using Kruskall Wallis and Mann-Whitney U tests.

RESULTS:

The median total, amniotic and allantoic HTP UCLs were 53.5 cm (interquartile range [IQR] 16), 29.5 cm (IQR 7) and 25.0 cm (IQR 8) respectively. Gestational age and amniotic UCL were moderately correlated (rho = 0.53, p = 0.04), with LOWESS estimating an exponential increase followed by plateauing at around Day 200. Nonlinear associations were observed between fetal weight and gestational age and CRL (adjusted r2 = 0.98 and 0.95 respectively). A linear association was observed between gestational age and CRL predicted CRL = -17.60 + 0.38 × gestational age, p < 0.001. MAIN

LIMITATIONS:

Limited availability of CNPs from mares dying during gestation. Estimated relationships can only approximate growth.

CONCLUSIONS:

This study provides important UCL and fetal size reference values, which may aid in assessing abnormalities. For the first time, associations between UCL and gestational age have been described.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Cordón Umbilical Tipo de estudio: Prognostic_studies Límite: Animals / Pregnancy Idioma: En Revista: Equine Vet J Año: 2024 Tipo del documento: Article País de afiliación: Reino Unido Pais de publicación: Estados Unidos
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Cordón Umbilical Tipo de estudio: Prognostic_studies Límite: Animals / Pregnancy Idioma: En Revista: Equine Vet J Año: 2024 Tipo del documento: Article País de afiliación: Reino Unido Pais de publicación: Estados Unidos