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Theta-tACS modulates cerebellar-related motor functions and cerebellar-cortical connectivity.
Guerra, Andrea; Paparella, Giulia; Passaretti, Massimiliano; Costa, Davide; Birreci, Daniele; De Biase, Alessandro; Colella, Donato; Angelini, Luca; Cannavacciuolo, Antonio; Berardelli, Alfredo; Bologna, Matteo.
Afiliación
  • Guerra A; Parkinson and Movement Disorders Unit, Study Center on Neurodegeneration (CESNE), Department of Neuroscience, University of Padua, Padua, Italy; Padova Neuroscience Center (PNC), University of Padua, Padua, Italy.
  • Paparella G; IRCCS Neuromed, Pozzilli (IS) 86077, Italy; Department of Human Neurosciences, Sapienza University of Rome, Rome 00185, Italy.
  • Passaretti M; Department of Human Neurosciences, Sapienza University of Rome, Rome 00185, Italy.
  • Costa D; Department of Human Neurosciences, Sapienza University of Rome, Rome 00185, Italy.
  • Birreci D; Department of Human Neurosciences, Sapienza University of Rome, Rome 00185, Italy.
  • De Biase A; Department of Human Neurosciences, Sapienza University of Rome, Rome 00185, Italy.
  • Colella D; Department of Human Neurosciences, Sapienza University of Rome, Rome 00185, Italy.
  • Angelini L; IRCCS Neuromed, Pozzilli (IS) 86077, Italy.
  • Cannavacciuolo A; IRCCS Neuromed, Pozzilli (IS) 86077, Italy.
  • Berardelli A; IRCCS Neuromed, Pozzilli (IS) 86077, Italy; Department of Human Neurosciences, Sapienza University of Rome, Rome 00185, Italy.
  • Bologna M; IRCCS Neuromed, Pozzilli (IS) 86077, Italy; Department of Human Neurosciences, Sapienza University of Rome, Rome 00185, Italy. Electronic address: matteo.bologna@uniroma1.it.
Clin Neurophysiol ; 158: 159-169, 2024 02.
Article en En | MEDLINE | ID: mdl-38219405
ABSTRACT

OBJECTIVE:

To evaluate the effects of cerebellar transcranial alternating current stimulation (tACS) delivered at cerebellar-resonant frequencies, i.e., theta (θ) and gamma (γ), on upper limb motor performance and cerebellum-primary motor cortex (M1) connectivity, as assessed by cerebellar-brain inhibition (CBI), in healthy subjects.

METHODS:

Participants underwent cerebellar-tACS while performing three cerebellar-dependent motor tasks (i) rhythmic finger-tapping, (ii) arm reaching-to-grasp ('grasping') and (iii) arm reaching-to-point ('pointing') an object. Also, we evaluated possible changes in CBI during cerebellar-tACS.

RESULTS:

θ-tACS decreased movement regularity during the tapping task and increased the duration of the pointing task compared to sham- and γ-tACS. Additionally, θ-tACS increased the CBI effectiveness (greater inhibition). The effect of θ-tACS on movement rhythm correlated with CBI changes and less tapping regularity corresponded to greater CBI.

CONCLUSIONS:

Cerebellar-tACS delivered at the θ frequency modulates cerebellar-related motor behavior and this effect is, at least in part, mediated by changes in the cerebellar inhibitory output onto M1. The effects of θ-tACS may be due to the modulation of cerebellar neurons that resonate to the θ rhythm.

SIGNIFICANCE:

These findings contribute to a better understanding of the physiological mechanisms of motor control and provide new evidence on cerebellar non-invasive brain stimulation.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Estimulación Transcraneal de Corriente Directa / Corteza Motora Límite: Humans Idioma: En Revista: Clin Neurophysiol Asunto de la revista: NEUROLOGIA / PSICOFISIOLOGIA Año: 2024 Tipo del documento: Article País de afiliación: Italia Pais de publicación: Países Bajos
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Estimulación Transcraneal de Corriente Directa / Corteza Motora Límite: Humans Idioma: En Revista: Clin Neurophysiol Asunto de la revista: NEUROLOGIA / PSICOFISIOLOGIA Año: 2024 Tipo del documento: Article País de afiliación: Italia Pais de publicación: Países Bajos