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Socioeconomic inequalities in early adulthood disrupt the immune transcriptomic landscape via upstream regulators.
Ravi, Sudharshan; Shanahan, Michael J; Levitt, Brandt; Harris, Kathleen Mullan; Cole, Steven W.
Afiliación
  • Ravi S; Jacobs Center for Productive Youth Development, University of Zürich, Andreasstrasse 15, 8050, Zürich, Switzerland. sudharshan.ravi@jacobscenter.uzh.ch.
  • Shanahan MJ; Jacobs Center for Productive Youth Development, University of Zürich, Andreasstrasse 15, 8050, Zürich, Switzerland.
  • Levitt B; Department of Sociology, University of Zürich, 8050, Zürich, Switzerland.
  • Harris KM; Carolina Population Center, University of North Carolina at Chapel Hill, Chapel Hill, NC, 27516, USA.
  • Cole SW; Carolina Population Center, University of North Carolina at Chapel Hill, Chapel Hill, NC, 27516, USA.
Sci Rep ; 14(1): 1255, 2024 01 13.
Article en En | MEDLINE | ID: mdl-38218990
ABSTRACT
Disparities in socio-economic status (SES) predict many immune system-related diseases, and previous research documents relationships between SES and the immune cell transcriptome. Drawing on a bioinformatically-informed network approach, we situate these findings in a broader molecular framework by examining the upstream regulators of SES-associated transcriptional alterations. Data come from the National Longitudinal Study of Adolescent to Adult Health (Add Health), a nationally representative sample of 4543 adults in the United States. Results reveal a network-of differentially expressed genes, transcription factors, and protein neighbors of transcription factors-that shows widespread SES-related dysregulation of the immune system. Mediational models suggest that body mass index (BMI) plays a key role in accounting for many of these associations. Overall, the results reveal the central role of upstream regulators in socioeconomic differences in the molecular basis of immunity, which propagate to increase risk of chronic health conditions in later-life.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Clase Social / Transcriptoma Tipo de estudio: Observational_studies / Prognostic_studies / Risk_factors_studies Aspecto: Determinantes_sociais_saude / Equity_inequality Límite: Adolescent / Adult / Humans País/Región como asunto: America do norte Idioma: En Revista: Sci Rep Año: 2024 Tipo del documento: Article País de afiliación: Suiza Pais de publicación: Reino Unido
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Clase Social / Transcriptoma Tipo de estudio: Observational_studies / Prognostic_studies / Risk_factors_studies Aspecto: Determinantes_sociais_saude / Equity_inequality Límite: Adolescent / Adult / Humans País/Región como asunto: America do norte Idioma: En Revista: Sci Rep Año: 2024 Tipo del documento: Article País de afiliación: Suiza Pais de publicación: Reino Unido