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Antioxidant and Antidiabetic Potential of Ormocarpum cochinchinense (Lour.) Merr. Leaf: An Integrated In vitro and In silico Approach.
Katturajan, Ramkumar; Shivaji, Priyadharshini; Nithiyanandam, Sangeetha; Parthasarathy, Manisha; Magesh, Shalini; Vashishth, Rahul; Radhakrishnan, Vidya; Prince, Sabina Evan.
Afiliación
  • Katturajan R; Department of Biotechnology, School of Bio Sciences and Technology, Vellore Institute of Technology, Vellore, 632014.
  • Shivaji P; Department of Biotechnology, School of Bio Sciences and Technology, Vellore Institute of Technology, Vellore, 632014.
  • Nithiyanandam S; Department of Biotechnology, School of Bio Sciences and Technology, Vellore Institute of Technology, Vellore, 632014.
  • Parthasarathy M; Department of Biotechnology, School of Bio Sciences and Technology, Vellore Institute of Technology, Vellore, 632014.
  • Magesh S; MGM Healthcare, Aminjikarai, Chennai, 600029, India.
  • Vashishth R; Department of Biosciences, School of Biosciences and Technology, VIT, Vellore, 632014.
  • Radhakrishnan V; VIT School of Agricultural Innovations and Advanced Learning, Vellore Institute of Technology, Vellore, 632014, India.
  • Prince SE; Department of Biotechnology, School of Bio Sciences and Technology, Vellore Institute of Technology, Vellore, 632014.
Chem Biodivers ; 21(2): e202300960, 2024 Feb.
Article en En | MEDLINE | ID: mdl-38217335
ABSTRACT
Diabetes is a prevalent metabolic disorder associated with various complications. Inhibition of α-glucosidase and α-amylase enzymes is an effective strategy for managing non-insulin-dependent diabetes mellitus. This study aimed to investigate the antioxidant and antidiabetic potential of Ormocarpum cochinchinense leaf through in vitro and in silico approaches. The methanol extract exhibited the highest phenolic and flavonoid content over solvent extracts aqueous, acetone, hexane, and chloroform, the same has been correlating with strong antioxidant activity. Furthermore, the methanol extract demonstrated significant inhibitory effects on α-amylase and α-glucosidase enzymes, indicating its potential as an antidiabetic agent. Molecular docking analysis identified compounds, including myo-inositol, with favorable binding energies comparable to the standard drug metformin. The selected compounds displayed strong binding affinity towards α-amylase and α-glucosidase enzymes. Structural dynamics analysis revealed that myo-inositol formed a more stable complex with the enzymes. These findings suggest that O. cochinchinense leaf possesses antioxidant and antidiabetic properties, making it a potential source for developing therapeutic agents.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Hipoglucemiantes / Antioxidantes Tipo de estudio: Prognostic_studies Idioma: En Revista: Chem Biodivers Asunto de la revista: BIOQUIMICA / QUIMICA Año: 2024 Tipo del documento: Article Pais de publicación: Suiza
Texto completo
Añadir a Mi BVS
Imprimir
XML
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Hipoglucemiantes / Antioxidantes Tipo de estudio: Prognostic_studies Idioma: En Revista: Chem Biodivers Asunto de la revista: BIOQUIMICA / QUIMICA Año: 2024 Tipo del documento: Article Pais de publicación: Suiza