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Insights into optimizing exosome therapies for acute skin wound healing and other tissue repair.
Sun, Tianjing; Li, Mo; Liu, Qi; Yu, Anyong; Cheng, Kun; Ma, Jianxing; Murphy, Sean; McNutt, Patrick Michael; Zhang, Yuanyuan.
Afiliación
  • Sun T; Department of Emergency, Affiliated Hospital of Zunyi Medical University, Zunyi, 563003, China.
  • Li M; Department of Emergency, Affiliated Hospital of Zunyi Medical University, Zunyi, 563003, China.
  • Liu Q; Department of Nephrology, Affiliated Hospital of Zunyi Medical University, Zunyi, 563003, China. liuqi1964@hotmail.com.
  • Yu A; Department of Emergency, Affiliated Hospital of Zunyi Medical University, Zunyi, 563003, China. anyongyu@163.com.
  • Cheng K; Division of Pharmacology and Pharmaceutical Sciences, School of Pharmacy, University of Missouri-Kansas City, Kansas City, MO, 64108, USA.
  • Ma J; Department of Biochemistry, Wake Forest University School of Medicine, Winston-Salem, NC, 27157, USA.
  • Murphy S; Wake Forest Institute of Regenerative Medicine, Wake Forest School of Medicine, Winston-Salem, NC, 27109, USA.
  • McNutt PM; Wake Forest Institute of Regenerative Medicine, Wake Forest School of Medicine, Winston-Salem, NC, 27109, USA.
  • Zhang Y; Wake Forest Institute of Regenerative Medicine, Wake Forest School of Medicine, Winston-Salem, NC, 27109, USA. yzhang@wakehealth.edu.
Front Med ; 18(2): 258-284, 2024 Apr.
Article en En | MEDLINE | ID: mdl-38216854
ABSTRACT
Exosome therapy holds great promise as a novel approach to improve acute skin wound healing. This review provides a comprehensive overview of the current understanding of exosome biology and its potential applications in acute skin wound healing and beyond. Exosomes, small extracellular vesicles secreted by various stem cells, have emerged as potent mediators of intercellular communication and tissue repair. One advantage of exosome therapy is its ability to avoid potential risks associated with stem cell therapy, such as immune rejection or stem cells differentiating into unwanted cell types. However, further research is necessary to optimize exosome therapy, not only in the areas of exosome isolation, characterization, and engineering, but also in determining the optimal dose, timing, administration, and frequency of exosome therapy. Thus, optimization of exosome therapy is critical for the development of more effective and safer exosome-based therapies for acute skin wound healing and other diseases induced by cancer, ischemia, or inflammation. This review provides valuable insights into the potential of exosome therapy and highlights the need for further research to optimize exosome therapy for clinical use.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Piel / Cicatrización de Heridas / Exosomas Límite: Animals / Humans Idioma: En Revista: Front Med Año: 2024 Tipo del documento: Article País de afiliación: China Pais de publicación: China
Texto completo
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Imprimir
XML
PubMed Links
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Piel / Cicatrización de Heridas / Exosomas Límite: Animals / Humans Idioma: En Revista: Front Med Año: 2024 Tipo del documento: Article País de afiliación: China Pais de publicación: China