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Value of high-speed videoendoscopy as an auxiliary tool in differentiation of benign and malignant unilateral vocal lesions.
Malinowski, Jakub; Pietruszewska, Wioletta; Kowalczyk, Magdalena; Niebudek-Bogusz, Ewa.
Afiliación
  • Malinowski J; Department of Otolaryngology, Head and Neck Oncology, Medical University of Lodz, Lodz, Poland. jakub.tomasz.malinowski@umed.lodz.pl.
  • Pietruszewska W; Department of Otolaryngology, Head and Neck Oncology, Medical University of Lodz, Lodz, Poland.
  • Kowalczyk M; Department of Otolaryngology, Head and Neck Oncology, Medical University of Lodz, Lodz, Poland.
  • Niebudek-Bogusz E; Department of Otolaryngology, Head and Neck Oncology, Medical University of Lodz, Lodz, Poland.
J Cancer Res Clin Oncol ; 150(1): 10, 2024 Jan 13.
Article en En | MEDLINE | ID: mdl-38216796
ABSTRACT

PURPOSE:

The study aimed to assess the relevance of objective vibratory parameters derived from high-speed videolaryngoscopy (HSV) as a supporting tool, to assist clinicians in establishing the initial diagnosis of benign and malignant glottal organic lesions.

METHODS:

The HSV examinations were conducted in 175

subjects:

50 normophonic, 85 subjects with benign vocal fold lesions, and 40 with early glottic cancer; organic lesions were confirmed by histopathologic examination. The parameters, derived from HSV kymography amplitude, symmetry, and glottal dynamic characteristics, were compared statistically between the groups with the following ROC analysis.

RESULTS:

Among 14 calculated parameters, 10 differed significantly between the groups. Four of them, the average resultant amplitude of the involved vocal fold (AmpInvolvedAvg), average amplitude asymmetry for the whole glottis and its middle third part (AmplAsymAvg; AmplAsymAvg_2/3), and absolute average phase difference (AbsPhaseDiffAvg), showed significant differences between benign and malignant lesions. Amplitude values were decreasing, while asymmetry and phase difference values were increasing with the risk of malignancy. In ROC analysis, the highest AUC was observed for AmpAsymAvg (0.719; p < 0.0001), and next in order was AmpInvolvedAvg (0.70; p = 0.0002).

CONCLUSION:

The golden standard in the diagnosis of organic lesions of glottis remains clinical examination with videolaryngoscopy, confirmed by histopathological examination. Our results showed that measurements of amplitude, asymmetry, and phase of vibrations in malignant vocal fold masses deteriorate significantly in comparison to benign vocal lesions. High-speed videolaryngoscopy could aid their preliminary differentiation noninvasively before histopathological examination; however, further research on larger groups is needed.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Fonación / Laringoscopía Límite: Humans Idioma: En Revista: J Cancer Res Clin Oncol Año: 2024 Tipo del documento: Article País de afiliación: Polonia Pais de publicación: Alemania
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Fonación / Laringoscopía Límite: Humans Idioma: En Revista: J Cancer Res Clin Oncol Año: 2024 Tipo del documento: Article País de afiliación: Polonia Pais de publicación: Alemania