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[Isolated liver involvement in Langerhans cell histiocytosis: A case report]. / Localisation hépatique isolée d'une histiocytose langerhansienne : à propos d'un cas.
Allaume, Pierre; Meneyrol, Eric; Bernard, Gontran; Houssel-Debry, Pauline; Emile, Jean-François; Turlin, Bruno.
Afiliación
  • Allaume P; Service d'anatomie pathologique, hôpital Pontchaillou, université de Rennes 1, CHU de Rennes, 2, rue Henri-Le-Guilloux, 35033 Rennes cedex 9, France. Electronic address: pallaume@laposte.net.
  • Meneyrol E; Service de radiologie, hôpital Pontchaillou, université de Rennes 1, CHU de Rennes, 2, rue Henri-Le-Guilloux, 35033 Rennes cedex 9, France.
  • Bernard G; Service de radiologie, hôpital Pontchaillou, université de Rennes 1, CHU de Rennes, 2, rue Henri-Le-Guilloux, 35033 Rennes cedex 9, France.
  • Houssel-Debry P; Service de maladies du foie, hôpital Pontchaillou, université de Rennes 1, CHU de Rennes, 2, rue Henri-Le-Guilloux, 35033 Rennes cedex 9, France.
  • Emile JF; Service d'anatomie pathologique et AP-HP, université de Versailles, Boulogne, France.
  • Turlin B; Service d'anatomie pathologique, hôpital Pontchaillou, université de Rennes 1, CHU de Rennes, 2, rue Henri-Le-Guilloux, 35033 Rennes cedex 9, France.
Ann Pathol ; 44(1): 69-74, 2024 Feb.
Article en Fr | MEDLINE | ID: mdl-38216436
ABSTRACT
Langerhans cell histiocytosis (LCH) is a disease whose physiopathology remains unclear, involving both inflammatory processes and clonal proliferation. It is observable at any given age, although about ten times more frequent in children than adults. Hepatic involvement is not rare, mostly part of a systemic disease, and linked to a poor prognosis. We report here a case of LCH with solitary hepatic involvement in a 74 year-old patient. This case demonstrated molecular anomaly of the MAPK pathway, BRAF N486_P490del. Through this observation, we precise the epidemiological and histological aspects and diagnostic criteria of this rare disease.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Histiocitosis de Células de Langerhans Tipo de estudio: Diagnostic_studies / Prognostic_studies Límite: Aged / Humans Idioma: Fr Revista: Ann Pathol Año: 2024 Tipo del documento: Article Pais de publicación: Francia
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Histiocitosis de Células de Langerhans Tipo de estudio: Diagnostic_studies / Prognostic_studies Límite: Aged / Humans Idioma: Fr Revista: Ann Pathol Año: 2024 Tipo del documento: Article Pais de publicación: Francia