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Neural circuit disruptions of eye gaze processing in autism spectrum disorder and schizophrenia: An activation likelihood estimation meta-analysis.
Ibrahim, Karim; Iturmendi-Sabater, Iciar; Vasishth, Maya; Barron, Daniel S; Guardavaccaro, MariaRose; Funaro, Melissa C; Holmes, Avram; McCarthy, Gregory; Eickhoff, Simon B; Sukhodolsky, Denis G.
Afiliación
  • Ibrahim K; Yale University School of Medicine, Child Study Center, United States of America. Electronic address: karim.ibrahim@yale.edu.
  • Iturmendi-Sabater I; Yale University School of Medicine, Child Study Center, United States of America.
  • Vasishth M; Yale University School of Medicine, Child Study Center, United States of America.
  • Barron DS; Brigham and Women's Hospital, Department of Psychiatry, Anesthesiology and Pain Medicine, United States of America; Harvard Medical School, Department of Psychiatry, United States of America.
  • Guardavaccaro M; Yale University School of Medicine, Child Study Center, United States of America.
  • Funaro MC; Yale University, Harvey Cushing/John Hay Whitney Medical Library, United States of America.
  • Holmes A; Yale University, Department of Psychology, United States of America; Yale University, Department of Psychiatry, United States of America; Yale University, Wu Tsai Institute, United States of America.
  • McCarthy G; Yale University, Department of Psychology, United States of America; Yale University, Wu Tsai Institute, United States of America.
  • Eickhoff SB; Institute of Systems Neuroscience, Medical Faculty, Heinrich Heine University Düsseldorf, Düsseldorf, Germany; Institute of Neuroscience and Medicine, Brain and Behaviour (INM-7), Research Centre Jülich, Jülich, Germany.
  • Sukhodolsky DG; Yale University School of Medicine, Child Study Center, United States of America.
Schizophr Res ; 264: 298-313, 2024 Feb.
Article en En | MEDLINE | ID: mdl-38215566
ABSTRACT

BACKGROUND:

Impairment in social cognition, particularly eye gaze processing, is a shared feature common to autism spectrum disorder (ASD) and schizophrenia. However, it is unclear if a convergent neural mechanism also underlies gaze dysfunction in these conditions. The present study examined whether this shared eye gaze phenotype is reflected in a profile of convergent neurobiological dysfunction in ASD and schizophrenia.

METHODS:

Activation likelihood estimation (ALE) meta-analyses were conducted on peak voxel coordinates across the whole brain to identify spatial convergence. Functional coactivation with regions emerging as significant was assessed using meta-analytic connectivity modeling. Functional decoding was also conducted.

RESULTS:

Fifty-six experiments (n = 30 with schizophrenia and n = 26 with ASD) from 36 articles met inclusion criteria, which comprised 354 participants with ASD, 275 with schizophrenia and 613 healthy controls (1242 participants in total). In ASD, aberrant activation was found in the left amygdala relative to unaffected controls during gaze processing. In schizophrenia, aberrant activation was found in the right inferior frontal gyrus and supplementary motor area. Across ASD and schizophrenia, aberrant activation was found in the right inferior frontal gyrus and right fusiform gyrus during gaze processing. Functional decoding mapped the left amygdala to domains related to emotion processing and cognition, the right inferior frontal gyrus to cognition and perception, and the right fusiform gyrus to visual perception, spatial cognition, and emotion perception. These regions also showed meta-analytic connectivity to frontoparietal and frontotemporal circuitry.

CONCLUSION:

Alterations in frontoparietal and frontotemporal circuitry emerged as neural markers of gaze impairments in ASD and schizophrenia. These findings have implications for advancing transdiagnostic biomarkers to inform targeted treatments for ASD and schizophrenia.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Esquizofrenia / Trastorno del Espectro Autista Tipo de estudio: Prognostic_studies / Systematic_reviews Límite: Humans Idioma: En Revista: Schizophr Res Asunto de la revista: PSIQUIATRIA Año: 2024 Tipo del documento: Article Pais de publicación: Países Bajos
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Esquizofrenia / Trastorno del Espectro Autista Tipo de estudio: Prognostic_studies / Systematic_reviews Límite: Humans Idioma: En Revista: Schizophr Res Asunto de la revista: PSIQUIATRIA Año: 2024 Tipo del documento: Article Pais de publicación: Países Bajos