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Causal effects of gut microbiota in the development of lung cancer and its histological subtypes: A Mendelian randomization study.
Ma, Yunlei; Deng, Yuqing; Shao, Tingting; Cui, Yong; Shen, Yefeng.
Afiliación
  • Ma Y; Department of Thoracic Surgery, Beijing Friendship Hospital, Capital Medical University, Beijing, China.
  • Deng Y; Department of Thoracic Surgery, Beijing Friendship Hospital, Capital Medical University, Beijing, China.
  • Shao T; Department of Thoracic Surgery, Zhujiang Hospital, Southern Medical University, Guangzhou, China.
  • Cui Y; Department of Thoracic Surgery, Beijing Friendship Hospital, Capital Medical University, Beijing, China.
  • Shen Y; Department of Thoracic Surgery, Beijing Friendship Hospital, Capital Medical University, Beijing, China.
Thorac Cancer ; 15(6): 486-495, 2024 Feb.
Article en En | MEDLINE | ID: mdl-38214421
ABSTRACT

BACKGROUND:

Numerous studies have characterized the gut microbiome (GM) in lung cancer (LC). Yet, the causality between GM and LC and its subtypes remain uncharacterized.

METHODS:

Two-sample Mendelian randomization (MR) was designed to investigate the causal relationship between the GM and LC and its subtypes, using publicly available summary data of genome-wide association studies. The researchers ran two groups of MR analyses, including the genome-wide statistical significance threshold (5 × 10-8 ) and the locus-wide significance level (1 × 10-5 ).

RESULTS:

Using MR analysis, we ascertained 42 groups of GM that are intimately linked to LC and its subtypes at the locus-wide significance level. Of the 42 groups, 12 were in LC, nine in non-small cell lung cancer (NSCLC), six in small cell lung cancer (SCLC), two in lung adenocarcinomas, and 13 in lung squamous carcinomas. After false discovery rate correction, we still found a remarkable causal interaction between the Eubacterium ruminantium group and SCLC. Moreover, five groups of GM closely linked to LC and its subtypes were recognised at the genome-wide statistical significance threshold. This finding included one group each in LC, NSCLC and SCLC, two groups in lung adenocarcinoma and none in lung squamous carcinoma. None of the foregoing findings were heterogeneous or horizontal pleiotropy. Reverse MR revealed that genetic susceptibility to LC and its subtypes caused significant changes in three groups of GM.

CONCLUSION:

Our findings substantiate the causality between GM and LC and its subtypes. This study offers fresh insights into the function of GM in mediating the progression of LC.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Carcinoma de Células Escamosas / Carcinoma de Pulmón de Células no Pequeñas / Carcinoma Pulmonar de Células Pequeñas / Microbioma Gastrointestinal / Adenocarcinoma del Pulmón / Neoplasias Pulmonares Tipo de estudio: Clinical_trials Límite: Humans Idioma: En Revista: Thorac Cancer Año: 2024 Tipo del documento: Article País de afiliación: China Pais de publicación: Singapur
Texto completo
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XML
PubMed Links
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Carcinoma de Células Escamosas / Carcinoma de Pulmón de Células no Pequeñas / Carcinoma Pulmonar de Células Pequeñas / Microbioma Gastrointestinal / Adenocarcinoma del Pulmón / Neoplasias Pulmonares Tipo de estudio: Clinical_trials Límite: Humans Idioma: En Revista: Thorac Cancer Año: 2024 Tipo del documento: Article País de afiliación: China Pais de publicación: Singapur