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Combination of allopurinol with Dahuang Mudan Tang significantly improve kidney function and alleviate oxidative stress and inflammation of chronic kidney disease stage Ⅰ-Ⅲ patients with hyperuricemia.
Congcong, Fang; Xiaoliang, Zhu; Yongjian, Zhang; Huan, Q I; Yingjie, Zhang.
Afiliación
  • Congcong F; Department of Endocrinology, Qinhuangdao Hospital of Traditional Chinese Medicine, Qinhuangdao 066000, China.
  • Xiaoliang Z; Department of Nephrology, Qinhuangdao Hospital of Traditional Chinese Medicine, Qinhuangdao 066000, China.
  • Yongjian Z; Department of Endocrinology, Qinhuangdao Hospital of Traditional Chinese Medicine, Qinhuangdao 066000, China.
  • Huan QI; Department of Endocrinology, Qinhuangdao Hospital of Traditional Chinese Medicine, Qinhuangdao 066000, China.
  • Yingjie Z; Department of Nephrology, Qinhuangdao Hospital of Traditional Chinese Medicine, Qinhuangdao 066000, China.
J Tradit Chin Med ; 44(1): 182-187, 2024 Feb.
Article en En | MEDLINE | ID: mdl-38213253
ABSTRACT

OBJECTIVE:

To evaluate the effect of Dahuang Mudan Tang (, DHMD) and allopurinol on the treatment of chronic kidney disease staged G1-G3b patients with hyperuricemia and to provide novel insights into the clinical management of chronic kidney disease complications.

METHODS:

A total of 80 chronic kidney patients staged G1-G3b with hyperuricemia were randomly grouped to receive single allopurinol treatment (control) and combined treatment with DHMD (treated) for 8 weeks. The kidney function and proteinuria indicators of patients were compared between pre-and post-treatment. The oxidative stress and inflammation responses were evaluated by corresponding indicators and cytokines. The clinical efficiency rate and adverse reaction events were also summarized to assess the therapeutic efficiency and safety.

RESULTS:

The kidney function and proteinuria of enrolled patients were alleviated after their therapies, behaved as the increasing estimated glomerular filtration rate and decreasing serum creatinine, serum uric acid, urea nitrogen, 24 h urine protein levels. On the other hand, the malondialdehyde level and pro-inflammation cytokines were suppressed by the therapies, and the superoxide dismutase was found to be significantly enhanced. Patients in the treated groups showed a better recovery in kidney function, proteinuria, oxidative stress, and inflammation response. Moreover, patients in the treated group showed a higher efficiency rate (95%) and fewer adverse reaction events (5%).

CONCLUSIONS:

The combination of allopurinol with DHMD significantly promoted the recovery of chronic kidney disease stage G1-G3b patients with hyperuricemia, which can be considered a novel clinical therapeutic strategy.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Hiperuricemia / Insuficiencia Renal Crónica Límite: Humans Idioma: En Revista: J Tradit Chin Med Año: 2024 Tipo del documento: Article País de afiliación: China Pais de publicación: China
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Hiperuricemia / Insuficiencia Renal Crónica Límite: Humans Idioma: En Revista: J Tradit Chin Med Año: 2024 Tipo del documento: Article País de afiliación: China Pais de publicación: China