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Astragaloside IV targeting autophagy of T cells improves inflammation of asthma.
Yang, Qing-Qing; Zhang, Hong-Ying; Duan, Xiao-Hong; Li, Mi-Hui; Sun, Jing; Tian, Li-Xia; Dong, Jing-Cheng; Kong, Ling-Wen.
Afiliación
  • Yang QQ; Shanghai Public Health Clinical Center Affiliated to Fudan University, Shanghai 200040, China.
  • Zhang HY; Institute of Integrated Traditional Chinese and Western Medicine, Huashan Hospital Affiliated to Fudan University, Shanghai 200040, China.
  • Duan XH; Institute of Integrated Traditional Chinese and Western Medicine, Huashan Hospital Affiliated to Fudan University, Shanghai 200040, China.
  • Li MH; Department of Integrated Traditional Chinese and Western Medicine, Huashan Hospital Affiliated to Fudan University, Shanghai 201508, China.
  • Sun J; Institute of Integrated Traditional Chinese and Western Medicine, Huashan Hospital Affiliated to Fudan University, Shanghai 200040, China.
  • Tian LX; Institute of Integrated Traditional Chinese and Western Medicine, Huashan Hospital Affiliated to Fudan University, Shanghai 200040, China.
  • Dong JC; Longhua Hospital Shanghai University of Traditional Chinese Medicine, Shanghai 201508, China.
  • Kong LW; Institute of Integrated Traditional Chinese and Western Medicine, Huashan Hospital Affiliated to Fudan University, Shanghai 200040, China.
J Asian Nat Prod Res ; 26(6): 699-713, 2024 Jun.
Article en En | MEDLINE | ID: mdl-38213072
ABSTRACT
Astragaloside IV (AST) has been confirmed to have antiasthmatic effects. However, the underline mechanism is unclear. The study aimed to explore the treatment mechanism of AST based on autophagy of memory T cells. AST treatment significantly decreased the number of T effector cells in asthma mice blood and the nude mice that received AST-treated TCMs had relieved inflammation compared with the untreated group; meanwhile, we found that AST significantly decreased the autophagy level and inhibited OX40/OX40L signal pathway of lymphocytes. The results highlighted that AST regulated autophagy to inhibit differentiation of effector T-cell phenotype.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Asma / Saponinas / Autofagia / Triterpenos / Linfocitos T / Inflamación Límite: Animals Idioma: En Revista: J Asian Nat Prod Res Asunto de la revista: BOTANICA / QUIMICA Año: 2024 Tipo del documento: Article País de afiliación: China Pais de publicación: Reino Unido
Texto completo
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PubMed Links
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Asma / Saponinas / Autofagia / Triterpenos / Linfocitos T / Inflamación Límite: Animals Idioma: En Revista: J Asian Nat Prod Res Asunto de la revista: BOTANICA / QUIMICA Año: 2024 Tipo del documento: Article País de afiliación: China Pais de publicación: Reino Unido