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Putative causal relations among gut flora, serums metabolites and arrhythmia: a Mendelian randomization study.
Li, Kaiyuan; Liu, Peng; Liu, Miao; Ye, Jun; Zhu, Li.
Afiliación
  • Li K; Graduate School of Dalian Medical University, Dalian Medical University, Dalian, China.
  • Liu P; Department of Cardiovascular Medicine, The Affiliated Taizhou People's Hospital of Nanjing Medical University, No. 399 Hailing South Road, Taizhou, Jiangsu Province, China.
  • Liu M; Department of Cardiovascular Medicine, The Second Affiliated Hospital of Nanchang University, Nanchang, China.
  • Ye J; Department of Cardiovascular Medicine, Central Hospital Affiliated to Shandong First Medical University, Jinan, China.
  • Zhu L; Department of Cardiovascular Medicine, The Affiliated Taizhou People's Hospital of Nanjing Medical University, No. 399 Hailing South Road, Taizhou, Jiangsu Province, China.
BMC Cardiovasc Disord ; 24(1): 38, 2024 Jan 11.
Article en En | MEDLINE | ID: mdl-38212687
ABSTRACT

BACKGROUND:

The pathogenesis of cardiac arrhythmias is multifaceted, encompassing genetic, environmental, hemodynamic, and various causative factors. Emerging evidence underscores a plausible connection between gut flora, serum metabolites, and specific types of arrhythmias. Recognizing the role of host genetics in shaping the microbiota, we employed two-sample Mendelian randomization analyses to investigate potential causal associations between gut flora, serum metabolites, and distinct arrhythmias.

METHODS:

Mendelian randomization methods were deployed to ascertain causal relationships between 211 gut flora, 575 serum metabolites, and various types of arrhythmias. To ensure the reliability of the findings, five complementary Mendelian randomization methods, including inverse variance weighting methods, were employed. The robustness of the results was scrutinized through a battery of sensitivity analyses, incorporating the Cochran Q test, leave-one-out test, and MR-Egger intercept analysis.

RESULTS:

Eighteen gut flora and twenty-six serum metabolites demonstrated associations with the risk of developing atrial fibrillation. Moreover, ten gut flora and fifty-two serum metabolites were linked to the risk of developing supraventricular tachycardia, while eight gut flora and twenty-five serum metabolites were associated with the risk of developing tachycardia. Additionally, six gut flora and twenty-one serum metabolites exhibited associations with the risk of developing bradycardia.

CONCLUSION:

This study revealed the potential causal relationship that may exist between gut flora, serum metabolites and different cardiac arrhythmias and highlights the need for further exploration. This study provides new perspectives to enhance diagnostic and therapeutic strategies in the field of cardiac arrhythmias.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Fibrilación Atrial / Microbioma Gastrointestinal Tipo de estudio: Clinical_trials Límite: Humans Idioma: En Revista: BMC Cardiovasc Disord Asunto de la revista: ANGIOLOGIA / CARDIOLOGIA Año: 2024 Tipo del documento: Article País de afiliación: China Pais de publicación: Reino Unido
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Fibrilación Atrial / Microbioma Gastrointestinal Tipo de estudio: Clinical_trials Límite: Humans Idioma: En Revista: BMC Cardiovasc Disord Asunto de la revista: ANGIOLOGIA / CARDIOLOGIA Año: 2024 Tipo del documento: Article País de afiliación: China Pais de publicación: Reino Unido