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Latent Tuberculosis Infection Testing Practices in a Large US Integrated Healthcare System.
Ku, Jennifer H; Fischer, Heidi; Qian, Lei X; Li, Kris; Skarbinski, Jacek; Shaw, Sally; Bruxvoort, Katia J; Lewin, Bruno J; Spence, Brigitte C; Tartof, Sara Y.
Afiliación
  • Ku JH; Department of Research & Evaluation, Kaiser Permanente Southern California, Pasadena, California, USA.
  • Fischer H; Department of Research & Evaluation, Kaiser Permanente Southern California, Pasadena, California, USA.
  • Qian LX; Department of Research & Evaluation, Kaiser Permanente Southern California, Pasadena, California, USA.
  • Li K; Department of Research & Evaluation, Kaiser Permanente Southern California, Pasadena, California, USA.
  • Skarbinski J; Division of Research, Kaiser Permanente Northern California, Oakland, California, USA.
  • Shaw S; Department of Research & Evaluation, Kaiser Permanente Southern California, Pasadena, California, USA.
  • Bruxvoort KJ; Department of Research & Evaluation, Kaiser Permanente Southern California, Pasadena, California, USA.
  • Lewin BJ; Department of Epidemiology, University of Alabama at Birmingham, Birmingham, Alabama, USA.
  • Spence BC; Department of Research & Evaluation, Kaiser Permanente Southern California, Pasadena, California, USA.
  • Tartof SY; Department of Research & Evaluation, Kaiser Permanente Southern California, Pasadena, California, USA.
Clin Infect Dis ; 78(5): 1304-1312, 2024 May 15.
Article en En | MEDLINE | ID: mdl-38207124
ABSTRACT

BACKGROUND:

Tuberculosis (TB) is a public health threat, with >80% of active TB in the United States occurring due to reactivation of latent TB infection (LTBI). We may be underscreening those with high risk for LTBI and overtesting those at lower risk. A better understanding of gaps in current LTBI testing practices in relation to LTBI test positivity is needed.

METHODS:

This study, conducted between 1 January 2008 and 31 December 2019 at Kaiser Permanente Southern California, included individuals aged ≥18 years without a history of active TB. We examined factors associated with LTBI testing and LTBI positivity.

RESULTS:

Among 3 816 884 adults (52% female, 37% White, 37% Hispanic, mean age 43.5 years [standard deviation, 16.1]), 706 367 (19%) were tested for LTBI, among whom 60 393 (9%) had ≥1 positive result. Among 1 211 971 individuals who met ≥1 screening criteria for LTBI, 210 025 (17%) were tested for LTBI. Factors associated with higher adjusted odds of testing positive included male sex (1.32; 95% confidence interval, 1.30-1.35), Asian/Pacific Islander (2.78, 2.68-2.88), current smoking (1.24, 1.20-1.28), diabetes (1.13, 1.09-1.16), hepatitis B (1.45, 1.34-1.57), hepatitis C (1.54, 1.44-1.66), and birth in a country with an elevated TB rate (3.40, 3.31-3.49). Despite being risk factors for testing positive for LTBI, none of these factors were associated with higher odds of LTBI testing.

CONCLUSIONS:

Current LTBI testing practices may be missing individuals at high risk of LTBI. Additional work is needed to refine and implement screening guidelines that appropriately target testing for those at highest risk for LTBI.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Tamizaje Masivo / Prestación Integrada de Atención de Salud / Tuberculosis Latente Tipo de estudio: Guideline / Risk_factors_studies Límite: Adolescent / Adult / Aged / Female / Humans / Male / Middle aged País/Región como asunto: America do norte Idioma: En Revista: Clin Infect Dis Asunto de la revista: DOENCAS TRANSMISSIVEIS Año: 2024 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Estados Unidos
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Tamizaje Masivo / Prestación Integrada de Atención de Salud / Tuberculosis Latente Tipo de estudio: Guideline / Risk_factors_studies Límite: Adolescent / Adult / Aged / Female / Humans / Male / Middle aged País/Región como asunto: America do norte Idioma: En Revista: Clin Infect Dis Asunto de la revista: DOENCAS TRANSMISSIVEIS Año: 2024 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Estados Unidos