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In Vitro Screening and Lipid-Lowering Effect of Prickly Pear (Opuntia Ficus-Indica L. Mill.) Fruit Extracts in 3T3-L1 Pre-Adipocytes and Mature Adipocytes.
Eseberri, Itziar; Gómez-Maqueo, Andrea; Trepiana, Jenifer; Gómez-López, Iván; Proença, Carina; Cano, M Pilar; Portillo, Maria P.
Afiliación
  • Eseberri I; Nutrition and Obesity Group, Department of Nutrition and Food Science, University of the Basque Country (UPV/EHU) and Lucio Lascaray Research Institute, Vitoria, Spain. itziar.eseberri@ehu.eus.
  • Gómez-Maqueo A; Bioaraba Health Research Institute, Vitoria, Spain. itziar.eseberri@ehu.eus.
  • Trepiana J; CIBERobn Physiopathology of Obesity and Nutrition, Institute of Health Carlos III, Madrid, Spain. itziar.eseberri@ehu.eus.
  • Gómez-López I; Department of Biotechnology and Microbiology of Food, Institute of Food Science Research (CIAL, CSIC-UAM), Nicolás Cabrera 9, Madrid, 28049, Spain.
  • Proença C; Nutrition and Obesity Group, Department of Nutrition and Food Science, University of the Basque Country (UPV/EHU) and Lucio Lascaray Research Institute, Vitoria, Spain.
  • Cano MP; Bioaraba Health Research Institute, Vitoria, Spain.
  • Portillo MP; CIBERobn Physiopathology of Obesity and Nutrition, Institute of Health Carlos III, Madrid, Spain.
Plant Foods Hum Nutr ; 79(1): 143-150, 2024 Mar.
Article en En | MEDLINE | ID: mdl-38206481
ABSTRACT
Opuntia ficus-indica fruits have been widely used due to their nutritional composition and beneficial effects on health, particularly against chronic diseases such as diabetes, obesity, cardiovascular diseases and cancer, among others. In recent years, prickly pear peel and pulp extracts have been characterised, and a high number of bioactive compounds have been identified. This study aimed to analyse the triglyceride-lowering effect of prickly pear peel and pulp extracts obtained from fruits of three varieties (Pelota, Sanguinos, and Colorada) in 3T3-L1 maturing and mature adipocytes. At a concentration of 50 µg/mL, peel extracts from Colorada reduced triglyceride accumulation in pre-adipocytes and mature adipocytes. Additionally, at 25 µg/mL, Pelota peel extract decreased triglyceride content in mature adipocytes. Moreover, maturing pre-adipocytes treated with 50 and 25 µg/mL of Sanguinos pulp extract showed a reduction of triglyceride accumulation. In addition, the lipid-lowering effect of the main individual betalain and phenolic compounds standards were assayed. Piscidic acid and isorhamnetin glycoside (IG2), found in Colorada peel extract, were identified as the bioactive compounds that could contribute more notably to the triglyceride-lowering effect of the extract. Thus, the betalain and phenolic-rich extracts from Opuntia ficus indica fruits may serve as an effective tool in obesity management.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Opuntia Tipo de estudio: Diagnostic_studies / Screening_studies Límite: Animals Idioma: En Revista: Plant Foods Hum Nutr Asunto de la revista: BOTANICA / CIENCIAS DA NUTRICAO Año: 2024 Tipo del documento: Article País de afiliación: España Pais de publicación: Países Bajos
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Opuntia Tipo de estudio: Diagnostic_studies / Screening_studies Límite: Animals Idioma: En Revista: Plant Foods Hum Nutr Asunto de la revista: BOTANICA / CIENCIAS DA NUTRICAO Año: 2024 Tipo del documento: Article País de afiliación: España Pais de publicación: Países Bajos