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Treatment of cartilage defects in the patellofemoral joint with matrix-associated autologous chondrocyte implantation effectively improves pain, function, and radiological outcomes after 5-7 years.
Eichinger, Martin; Henninger, Benjamin; Petry, Benjamin; Schuster, Philipp; Herbst, Elmar; Wagner, Moritz; Rosenberger, Ralf; Mayr, Raul.
Afiliación
  • Eichinger M; Department of Orthopaedics and Traumatology, a.ö. Bezirkskrankenhaus St. Johann in Tirol, Bahnhofstraße 14, 6380, St. Johann in Tirol, Austria. martin.eichinger@khsj.at.
  • Henninger B; Department of Orthopaedics and Traumatology, Medical University of Innsbruck, Innsbruck, Austria. martin.eichinger@khsj.at.
  • Petry B; Department of Radiology, Medical University of Innsbruck, Innsbruck, Austria.
  • Schuster P; Department of Orthopaedics and Traumatology, Medical University of Innsbruck, Innsbruck, Austria.
  • Herbst E; Department of Orthopaedic Surgery, Waikato Hospital, Hamilton, New Zealand.
  • Wagner M; Department of Sports Orthopaedics and Special Joint Surgery, RKH Orthopaedic Hospital, Markgröningen, Germany.
  • Rosenberger R; Department of Orthopaedics and Traumatology, Paracelsus Medical University, Clinic Nuremberg, Nuremberg, Germany.
  • Mayr R; Department of Trauma, Hand and Reconstructive Surgery, University of Münster, Münster, Germany.
Arch Orthop Trauma Surg ; 144(4): 1655-1665, 2024 Apr.
Article en En | MEDLINE | ID: mdl-38206448
ABSTRACT

INTRODUCTION:

The aim of the present study was to evaluate midterm outcomes 5-7 years after matrix-associated autologous chondrocyte implantation (MACI) in the patellofemoral joint. MATERIALS AND

METHODS:

Twenty-six patients who had undergone MACI using the Novocart® 3D scaffold were prospectively evaluated. Clinical outcomes were determined by measuring the 36-Item Short-Form Health Survey (SF-36) and International Knee Documentation Committee (IKDC) scores and the Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC) values preoperatively and 3, 6, and 12 months, and a mean of 6 years postoperatively. At the final follow-up, the Magnetic Resonance Observation of Cartilage Repair Tissue (MOCART) score was evaluated.

RESULTS:

Twenty-two patients with 23 focal cartilage defects (19 patella and four trochlea) were available for the final follow-up. The mean defect size was 4.0 ± 1.9 cm2 (range 2.4-9.4 cm2). All clinical outcome scores improved significantly until 5-7 years after MACI (SF-36 score, 61.2 ± 19.6 to 83.2 ± 11.6; P = 0.001; IKDC score, 47.5 ± 20.6 to 74.7 ± 15.5; P < 0.001; and WOMAC, 29.8 ± 15.7 to 8.2 ± 10.3; P < 0.001). The mean MOCART score was 76.0 ± 11.0 at the final follow-up. Nineteen of the 22 patients (86.4%) were satisfied with the outcomes after 5-7 years and responded that they would undergo the procedure again.

CONCLUSION:

MACI in the patellofemoral joint demonstrated good midterm clinical results with a significant reduction in pain, improvement in function, and high patient satisfaction. These clinical findings are supported by radiological evidence from MOCART scores. LEVEL OF EVIDENCE IV-case series.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Cartílago Articular / Enfermedades de los Cartílagos / Articulación Patelofemoral / Traumatismos de la Rodilla Tipo de estudio: Risk_factors_studies Límite: Humans Idioma: En Revista: Arch Orthop Trauma Surg Año: 2024 Tipo del documento: Article País de afiliación: Austria Pais de publicación: Alemania
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Cartílago Articular / Enfermedades de los Cartílagos / Articulación Patelofemoral / Traumatismos de la Rodilla Tipo de estudio: Risk_factors_studies Límite: Humans Idioma: En Revista: Arch Orthop Trauma Surg Año: 2024 Tipo del documento: Article País de afiliación: Austria Pais de publicación: Alemania