Effects of social housing conditions on ethanol-induced behavioral sensitization in Swiss mice.
Psychopharmacology (Berl)
; 241(5): 987-1000, 2024 May.
Article
en En
| MEDLINE
| ID: mdl-38206359
ABSTRACT
RATIONALE In previous animal model studies, it was shown that drug sensitization is dependent upon physical environmental conditions. However, the effects of social housing conditions on drug sensitization is much less known. OBJECTIVE:
The aim of the present study was to investigate the effects of social conditions, through the size of housing groups, on ethanol stimulant effects and ethanol-induced behavioral sensitization in mice. MATERIALS ANDMETHODS:
Male and female Swiss mice were housed in groups of different sizes (isolated mice, two mice per cage, four mice per cage and eight mice per cage) during a six-week period. A standard paradigm of ethanol-induced locomotor sensitization was then started with one daily injection of 2.5 g/kg ethanol for 8 consecutive days.RESULTS:
The results show that social housing conditions affect the acute stimulant effects of ethanol. The highest stimulant effects were observed in socially isolated mice and then gradually decreased as the size of the group increased. Although the rate of ethanol sensitization did not differ between groups, the ultimate sensitized levels of ethanol-induced stimulant effects were significantly reduced in mice housed in groups of eight.CONCLUSIONS:
These results are consistent with the idea that higher levels of acute and sensitized ethanol stimulant effects are observed in mice housed in stressful housing conditions, such as social isolation.Palabras clave
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Depresores del Sistema Nervioso Central
/
Etanol
Límite:
Animals
Idioma:
En
Revista:
Psychopharmacology (Berl)
Año:
2024
Tipo del documento:
Article
País de afiliación:
Bélgica
Pais de publicación:
Alemania