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Concurrent Endometrial Cancer in Women with Atypical Endometrial Hyperplasia: What Is the Predictive Value of Patient Characteristics?
Giannella, Luca; Piva, Francesco; Delli Carpini, Giovanni; Di Giuseppe, Jacopo; Grelloni, Camilla; Giulietti, Matteo; Sopracordevole, Francesco; Giorda, Giorgio; Del Fabro, Anna; Clemente, Nicolò; Gardella, Barbara; Bogani, Giorgio; Brasile, Orsola; Martinello, Ruby; Caretto, Marta; Ghelardi, Alessandro; Albanesi, Gianluca; Stevenazzi, Guido; Venturini, Paolo; Papiccio, Maria; Cannì, Marco; Barbero, Maggiorino; Fambrini, Massimiliano; Maggi, Veronica; Uccella, Stefano; Spinillo, Arsenio; Raspagliesi, Francesco; Greco, Pantaleo; Simoncini, Tommaso; Petraglia, Felice; Ciavattini, Andrea.
Afiliación
  • Giannella L; Woman's Health Sciences Department, Gynecologic Section, Polytechnic University of Marche, 60123 Ancona, Italy.
  • Piva F; Department of Specialistic Clinical and Odontostomatological Sciences, Polytechnic University of Marche, 60131 Ancona, Italy.
  • Delli Carpini G; Woman's Health Sciences Department, Gynecologic Section, Polytechnic University of Marche, 60123 Ancona, Italy.
  • Di Giuseppe J; Woman's Health Sciences Department, Gynecologic Section, Polytechnic University of Marche, 60123 Ancona, Italy.
  • Grelloni C; Woman's Health Sciences Department, Gynecologic Section, Polytechnic University of Marche, 60123 Ancona, Italy.
  • Giulietti M; Department of Specialistic Clinical and Odontostomatological Sciences, Polytechnic University of Marche, 60131 Ancona, Italy.
  • Sopracordevole F; Gynecologic Oncology Unit, IRCCS-Centro di Riferimento Oncologico di Aviano, 33081 Aviano, Italy.
  • Giorda G; Gynecologic Oncology Unit, IRCCS-Centro di Riferimento Oncologico di Aviano, 33081 Aviano, Italy.
  • Del Fabro A; Gynecologic Oncology Unit, IRCCS-Centro di Riferimento Oncologico di Aviano, 33081 Aviano, Italy.
  • Clemente N; Gynecologic Oncology Unit, IRCCS-Centro di Riferimento Oncologico di Aviano, 33081 Aviano, Italy.
  • Gardella B; Department of Obstetrics and Gynecology, Fondazione IRCCS Policlinico San Matteo, Università degli Studi di Pavia, 27100 Pavia, Italy.
  • Bogani G; Gynecological Oncology Unit, Fondazione IRCCS-Istituto Nazionale Tumori, 20133 Milano, Italy.
  • Brasile O; Section of Obstetrics and Gynecology, Department of Medical Sciences, University of Ferrara, 44124 Ferrara, Italy.
  • Martinello R; Section of Obstetrics and Gynecology, Department of Medical Sciences, University of Ferrara, 44124 Ferrara, Italy.
  • Caretto M; Division of Obstetrics and Gynecology, Department of Clinical and Experimental Medicine, University of Pisa, 56124 Pisa, Italy.
  • Ghelardi A; UOC Ostetricia e Ginecologia, Ospedale Apuane, Azienda Usl Toscana Nord-Ovest, 54100 Massa, Italy.
  • Albanesi G; UOC Ostetricia e Ginecologia, Ospedale Apuane, Azienda Usl Toscana Nord-Ovest, 54100 Massa, Italy.
  • Stevenazzi G; Department of Obstetrics and Gynaecology, ASST Ovest MI, Legnano (Milan) Hospital, 20025 Legnano, Italy.
  • Venturini P; Division of Obstetrics and Gynecology, AUSL di Modena, 41012 Carpi, Italy.
  • Papiccio M; Division of Obstetrics and Gynecology, AUSL di Modena, 41012 Carpi, Italy.
  • Cannì M; Department of Obstetrics and Gynecology, Asti Community Hospital, 14100 Asti, Italy.
  • Barbero M; Department of Obstetrics and Gynecology, Asti Community Hospital, 14100 Asti, Italy.
  • Fambrini M; Obstetrics and Gynecology, Department of Experimental, Clinical, and Biomedical Sciences, Careggi University Hospital, University of Florence, 50121 Florence, Italy.
  • Maggi V; Department of Obstetrics and Gynecology, University of Verona, 37129 Verona, Italy.
  • Uccella S; Department of Obstetrics and Gynecology, University of Verona, 37129 Verona, Italy.
  • Spinillo A; Department of Obstetrics and Gynecology, Fondazione IRCCS Policlinico San Matteo, Università degli Studi di Pavia, 27100 Pavia, Italy.
  • Raspagliesi F; Gynecological Oncology Unit, Fondazione IRCCS-Istituto Nazionale Tumori, 20133 Milano, Italy.
  • Greco P; Section of Obstetrics and Gynecology, Department of Medical Sciences, University of Ferrara, 44124 Ferrara, Italy.
  • Simoncini T; Division of Obstetrics and Gynecology, Department of Clinical and Experimental Medicine, University of Pisa, 56124 Pisa, Italy.
  • Petraglia F; Obstetrics and Gynecology, Department of Experimental, Clinical, and Biomedical Sciences, Careggi University Hospital, University of Florence, 50121 Florence, Italy.
  • Ciavattini A; Woman's Health Sciences Department, Gynecologic Section, Polytechnic University of Marche, 60123 Ancona, Italy.
Cancers (Basel) ; 16(1)2023 Dec 29.
Article en En | MEDLINE | ID: mdl-38201599
ABSTRACT

BACKGROUND:

The rate of concurrent endometrial cancer (EC) in atypical endometrial hyperplasia (AEH) can be as high as 40%. Some patient characteristics showed associations with this occurrence. However, their real predictive power with related validation has yet to be discovered. The present study aimed to assess the performance of various models based on patient characteristics in predicting EC in women with AEH.

METHODS:

This is a retrospective multi-institutional study including women with AEH undergoing definitive surgery. The women were divided according to the final histology (EC vs. no-EC). The available cases were divided into a training and validation set. Using k-fold cross-validation, we built many predictive models, including regressions and artificial neural networks (ANN).

RESULTS:

A total of 193/629 women (30.7%) showed EC at hysterectomy. A total of 26/193 (13.4%) women showed high-risk EC. Regression and ANN models showed a prediction performance with a mean area under the curve of 0.65 and 0.75 on the validation set, respectively. Among the best prediction models, the most recurrent patient characteristics were age, body mass index, Lynch syndrome, diabetes, and previous breast cancer. None of these independent variables showed associations with high-risk diseases in women with EC.

CONCLUSIONS:

Patient characteristics did not show satisfactory performance in predicting EC in AEH. Risk stratification in AEH based mainly on patient characteristics may be clinically unsuitable.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Tipo de estudio: Prognostic_studies / Risk_factors_studies Idioma: En Revista: Cancers (Basel) Año: 2023 Tipo del documento: Article País de afiliación: Italia Pais de publicación: Suiza
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Tipo de estudio: Prognostic_studies / Risk_factors_studies Idioma: En Revista: Cancers (Basel) Año: 2023 Tipo del documento: Article País de afiliación: Italia Pais de publicación: Suiza