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Plasma proenkephalin A and incident chronic kidney disease and albuminuria in the REasons for Geographic And Racial Differences in Stroke (REGARDS) cohort.
Bullen, Alexander L; Katz, Ronit; Poursadrolah, Sayna; Short, Samuel A P; Long, D Leann; Cheung, Katharine L; Sharma, Shilpa; Al-Rousan, Tala; Fregoso, Alma; Schulte, Janin; Gutierrez, Orlando M; Shlipak, Michael G; Cushman, Mary; Ix, Joachim H; Rifkin, Dena E.
Afiliación
  • Bullen AL; Nephrology Section, Veterans Affairs San Diego Healthcare System, La Jolla, CA, USA. abullen@health.ucsd.edu.
  • Katz R; Division of Nephrology and Hypertension, Department of Medicine, University of California San Diego, San Diego, CA, USA. abullen@health.ucsd.edu.
  • Poursadrolah S; University of Washington, Seattle, WA, USA.
  • Short SAP; Department of Medicine, University of California San Diego, San Diego, CA, USA.
  • Long DL; University of North Carolina, Chapel Hill, North Carolina, USA.
  • Cheung KL; Department of Biostatistics, School of Public Health, University of Alabama at Birmingham, Birmingham, AL, USA.
  • Sharma S; Division of Nephrology, Larner College of Medicine, University of Vermont, Burlington, VT, USA.
  • Al-Rousan T; Division of Nephrology, David Geffen School of Medicine at UCLA, Los Angeles, CA, USA.
  • Fregoso A; Nephrology Section, Veteran Affairs Greater Los Angeles Healthcare System, Los Angeles, CA, USA.
  • Schulte J; Division of Preventive Medicine, Department of Family Medicine and Public Health, University of California San Diego, San Diego, CA, USA.
  • Gutierrez OM; School of Medicine, University of California San Diego, San Diego, CA, USA.
  • Shlipak MG; SphingoTec GmbH, Hennigsdorf, Germany.
  • Cushman M; Division of Nephrology, Department of Medicine, University of Alabama at Birmingham, Birmingham, AL, USA.
  • Ix JH; Kidney Health Research Collaborative, Department of Medicine, University of California, San Francisco, CA, USA.
  • Rifkin DE; Department of Medicine, San Francisco VA Medical Center, San Francisco, CA, USA.
BMC Nephrol ; 25(1): 16, 2024 Jan 10.
Article en En | MEDLINE | ID: mdl-38200454
ABSTRACT

BACKGROUND:

Plasma proenkephalin A (PENK-A) is a precursor of active enkephalins. Higher blood concentrations have been associated with estimated glomerular filtration rate (eGFR) decline in European populations. Due to the significant disparity in incident chronic kidney disease (CKD) between White and Black people, we evaluated the association of PENK-A with incident CKD and other kidney outcomes among a biracial cohort in the U.S.

METHODS:

In a nested cohort of 4,400 participants among the REasons for Geographic And Racial Differences in Stroke, we determined the association between baseline PENK-A concentration and incident CKD using the creatinine-cystatin C CKD-EPI 2021 equation without race coefficient, significant eGFR decline, and incident albuminuria between baseline and a follow-up visit 9.4 years later. We tested for race and sex interactions. We used inverse probability sampling weights to account for the sampling design.

RESULTS:

At baseline, mean (SD) age was 64 (8) years, 49% were women, and 52% were Black participants. 8.5% developed CKD, 21% experienced ≥ 30% decline in eGFR and 18% developed albuminuria. There was no association between PENK-A and incident CKD and no difference by race or sex. However, higher PENK-A was associated with increased odds of progressive eGFR decline (OR 1.12; 95% CI 1.00, 1.25). Higher PENK-A concentration was strongly associated with incident albuminuria among patients without diabetes mellitus (OR 1.29; 95% CI 1.09, 1.53).

CONCLUSION:

While PENK-A was not associated with incident CKD, its associations with progression of CKD and incident albuminuria, among patients without diabetes, suggest that it might be a useful tool in the evaluation of kidney disease among White and Black patients.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Precursores de Proteínas / Accidente Cerebrovascular / Insuficiencia Renal Crónica Tipo de estudio: Diagnostic_studies / Risk_factors_studies Límite: Female / Humans / Male / Middle aged Idioma: En Revista: BMC Nephrol Asunto de la revista: NEFROLOGIA Año: 2024 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Reino Unido
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Precursores de Proteínas / Accidente Cerebrovascular / Insuficiencia Renal Crónica Tipo de estudio: Diagnostic_studies / Risk_factors_studies Límite: Female / Humans / Male / Middle aged Idioma: En Revista: BMC Nephrol Asunto de la revista: NEFROLOGIA Año: 2024 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Reino Unido