Your browser doesn't support javascript.
loading
Defining the biogeographical map and potential bacterial translocation of microbiome in human 'surface organs'.
She, Jun-Jun; Liu, Wei-Xin; Ding, Xiao-Ming; Guo, Gang; Han, Jing; Shi, Fei-Yu; Lau, Harry Cheuk-Hay; Ding, Chen-Guang; Xue, Wu-Jun; Shi, Wen; Liu, Gai-Xia; Zhang, Zhe; Hu, Chen-Hao; Chen, Yinnan; Wong, Chi Chun; Yu, Jun.
Afiliación
  • She JJ; Department of General Surgery, First Affiliated Hospital of Xi'an Jiao Tong University, Xi'an, China. junjunshe1975@sina.com.
  • Liu WX; Center for Gut Microbiome Research, Med-X Institute Centre, First Affiliated Hospital of Xi'an Jiao Tong University, Xian, China. junjunshe1975@sina.com.
  • Ding XM; Department of Talent Highland, First Affiliated Hospital of Xi'an Jiao Tong University, Xi'an, China. junjunshe1975@sina.com.
  • Guo G; Yulin Hospital, First Affiliated Hospital of Xi'an Jiao Tong University, Yulin, China. junjunshe1975@sina.com.
  • Han J; Institute of Digestive Disease and The Department of Medicine and Therapeutics, State Key Laboratory of Digestive Disease, Li Ka Shing Institute of Health Sciences, CUHK Shenzhen Research Institute, The Chinese University of Hong Kong, Hong Kong SAR, China.
  • Shi FY; Department of Kidney Transplantation, The First Affiliated Hospital of Xi'an Jiao Tong University, Xi'an, China.
  • Lau HC; Institute of Organ Transplantation, Xi'an Jiao Tong University, Xi'an, China.
  • Ding CG; Center for Gut Microbiome Research, Med-X Institute Centre, First Affiliated Hospital of Xi'an Jiao Tong University, Xian, China.
  • Xue WJ; Department of Talent Highland, First Affiliated Hospital of Xi'an Jiao Tong University, Xi'an, China.
  • Shi W; Center for Gut Microbiome Research, Med-X Institute Centre, First Affiliated Hospital of Xi'an Jiao Tong University, Xian, China.
  • Liu GX; Department of Talent Highland, First Affiliated Hospital of Xi'an Jiao Tong University, Xi'an, China.
  • Zhang Z; Department of General Surgery, First Affiliated Hospital of Xi'an Jiao Tong University, Xi'an, China.
  • Hu CH; Center for Gut Microbiome Research, Med-X Institute Centre, First Affiliated Hospital of Xi'an Jiao Tong University, Xian, China.
  • Chen Y; Department of Talent Highland, First Affiliated Hospital of Xi'an Jiao Tong University, Xi'an, China.
  • Wong CC; Institute of Digestive Disease and The Department of Medicine and Therapeutics, State Key Laboratory of Digestive Disease, Li Ka Shing Institute of Health Sciences, CUHK Shenzhen Research Institute, The Chinese University of Hong Kong, Hong Kong SAR, China.
  • Yu J; Department of Kidney Transplantation, The First Affiliated Hospital of Xi'an Jiao Tong University, Xi'an, China.
Nat Commun ; 15(1): 427, 2024 Jan 10.
Article en En | MEDLINE | ID: mdl-38199995
ABSTRACT
The microbiome in a specific human organ has been well-studied, but few reports have investigated the multi-organ microbiome as a whole. Here, we aim to analyse the intra-individual inter-organ and intra-organ microbiome in deceased humans. We collected 1608 samples from 53 sites of 7 surface organs (oral cavity, esophagus, stomach, small intestine, appendix, large intestine and skin; n = 33 subjects) and performed microbiome profiling, including 16S full-length sequencing. Microbial diversity varied dramatically among organs, and core microbial species co-existed in different intra-individual organs. We deciphered microbial changes across distinct intra-organ sites, and identified signature microbes, their functional traits, and interactions specific to each site. We revealed significant microbial heterogeneity between paired mucosa-lumen samples of stomach, small intestine, and large intestine. Finally, we established the landscape of inter-organ relationships of microbes along the digestive tract. Therefore, we generate a catalogue of bacterial composition, diversity, interaction, functional traits, and bacterial translocation in human at inter-organ and intra-organ levels.
Asunto(s)
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Apéndice / Microbiota Límite: Humans Idioma: En Revista: Nat Commun Asunto de la revista: BIOLOGIA / CIENCIA Año: 2024 Tipo del documento: Article País de afiliación: China Pais de publicación: Reino Unido
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Apéndice / Microbiota Límite: Humans Idioma: En Revista: Nat Commun Asunto de la revista: BIOLOGIA / CIENCIA Año: 2024 Tipo del documento: Article País de afiliación: China Pais de publicación: Reino Unido