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20(S)-Ginsenoside Rg2 amino acid derivatives for anti hemorrhagic shock: Synthesis, characterization and evaluation.
Dong, Qinghai; Xie, Hongliu; Liu, Jiayin; Su, Jun; An, Yang; Shi, Fei; Lin, Fang; Liu, Jihua.
Afiliación
  • Dong Q; School of Pharmaceutical Sciences, Jilin University, Changchun 130021, PR China.
  • Xie H; School of Pharmaceutical Sciences, Jilin University, Changchun 130021, PR China.
  • Liu J; School of Pharmaceutical Sciences, Jilin University, Changchun 130021, PR China.
  • Su J; School of Pharmaceutical Sciences, Jilin University, Changchun 130021, PR China; Basic Medicine Department, Fenyang College of Shanxi Medical University, Fenyang 032200, PR China.
  • An Y; School of Pharmaceutical Sciences, Jilin University, Changchun 130021, PR China.
  • Shi F; School of Pharmaceutical Sciences, Jilin University, Changchun 130021, PR China.
  • Lin F; School of Pharmaceutical Sciences, Jilin University, Changchun 130021, PR China.
  • Liu J; School of Pharmaceutical Sciences, Jilin University, Changchun 130021, PR China. Electronic address: liujh@jlu.edu.cn.
J Pharm Biomed Anal ; 240: 115939, 2024 Mar 15.
Article en En | MEDLINE | ID: mdl-38198887
ABSTRACT
The purpose of this study is to screen a novel Rg2 derivative for anti hemorrhagic shock. Eight Rg2 amino acid ester derivatives were designed and synthesized, and their effects on hypoxia and shock were studied. Among them, the derivative 1 (D1) exhibited excellent anti hypoxia by promoting survival rate of H9c2 cells damaged by hypoxia. D1 improved physiological indicators of the rats in hemorrhagic shock, such as blood pressure, heart rate, lactate, acid-base balance, and alleviate oxidative stress and inflammatory damage. Its latent mechanisms were explored by a method of plasma metabolomics based on UPLC-QTOF-MS. As a result, a total of 16 biomarkers were identified involving 6 metabolic pathways. The results of this study contained that the derivative 1 could be considered as potent drug candidates for anti shock and deserved further research and development.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Choque Hemorrágico / Ginsenósidos Límite: Animals Idioma: En Revista: J Pharm Biomed Anal Año: 2024 Tipo del documento: Article Pais de publicación: Reino Unido
Texto completo
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XML
PubMed Links
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Choque Hemorrágico / Ginsenósidos Límite: Animals Idioma: En Revista: J Pharm Biomed Anal Año: 2024 Tipo del documento: Article Pais de publicación: Reino Unido