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Safety and efficacy of radiotherapy combined with chemotherapy for recurrent metastatic renal pelvic and ureteral carcinoma.
Liu, Ming-Zhu; Li, Xiao-Ying; Lyu, Feng; Gao, Xian-Shu; Chen, Jia-Yan; Gao, Yan; Xie, Mu; Ren, Xue-Ying; Ma, Ming-Wei.
Afiliación
  • Liu MZ; Department of Radiation Oncology, Peking University First Hospital, No. 7 Xishiku Street, Beijing, 100034, China.
  • Li XY; Department of Radiation Oncology, Peking University First Hospital, No. 7 Xishiku Street, Beijing, 100034, China.
  • Lyu F; Department of Radiation Oncology, Peking University First Hospital, No. 7 Xishiku Street, Beijing, 100034, China.
  • Gao XS; Department of Radiation Oncology, Peking University First Hospital, No. 7 Xishiku Street, Beijing, 100034, China. doctorgaoxs@126.com.
  • Chen JY; Department of Radiation Oncology, Peking University First Hospital, No. 7 Xishiku Street, Beijing, 100034, China.
  • Gao Y; Department of Radiation Oncology, Peking University First Hospital, No. 7 Xishiku Street, Beijing, 100034, China.
  • Xie M; Department of Radiation Oncology, Peking University First Hospital, No. 7 Xishiku Street, Beijing, 100034, China.
  • Ren XY; Department of Radiation Oncology, Peking University First Hospital, No. 7 Xishiku Street, Beijing, 100034, China.
  • Ma MW; Department of Radiation Oncology, Peking University First Hospital, No. 7 Xishiku Street, Beijing, 100034, China. shandianmcqueen@163.com.
World J Urol ; 42(1): 23, 2024 Jan 10.
Article en En | MEDLINE | ID: mdl-38197979
ABSTRACT

PURPOSE:

To retrospectively investigate the safety and efficacy of radiotherapy combined with chemotherapy for recurrent metastatic renal pelvic and ureteral carcinoma.

METHODS:

109 patients were enrolled in this study, including 44 patients in the radiochemotherapy group and 65 patients in the chemotherapy group. Propensity score matching (PSM) was used to balance the baseline characteristics of the two groups by 11 matching. Kaplan-Meier method was used to calculate PFS and OS. Cox regression model was used for multivariate analysis. The side effects were evaluated by CTCAE v5.0

RESULTS:

The median follow-up time was 14.5 months. Multivariate analysis showed that radiotherapy was a good independent prognostic factor for OS (HR 0.327, 95% CI 0.157-0.680, P = 0.003). After matching, there were 40 patients in both groups, and the median PFS and OS in the radiochemotherapy group were longer than those in the chemotherapy group (PFS 10.4 vs. 6.7 months, P = 0.035; OS 43.5 vs. 18.8 months, P < 0.001). In addition, in the radiochemotherapy group, patients treated with radiotherapy before first-line chemotherapy failure had a longer PFS than those treated with radiotherapy after chemotherapy failure (median PFS 15.7 vs. 6 months, P = 0.003). There was no significant difference in the incidence of grade 3-4 toxicities between the two groups (52.3% vs. 50.8%, P = 0.878).

CONCLUSION:

For patients with recurrent metastatic renal pelvic and ureteral carcinoma, radiotherapy combined with chemotherapy is well tolerable and expected to bring long-term survival benefits, and the benefits of early interventional radiotherapy may be more obvious.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Neoplasias Ureterales / Carcinoma Tipo de estudio: Observational_studies / Prognostic_studies / Risk_factors_studies Límite: Humans Idioma: En Revista: World J Urol Año: 2024 Tipo del documento: Article País de afiliación: China Pais de publicación: Alemania
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Neoplasias Ureterales / Carcinoma Tipo de estudio: Observational_studies / Prognostic_studies / Risk_factors_studies Límite: Humans Idioma: En Revista: World J Urol Año: 2024 Tipo del documento: Article País de afiliación: China Pais de publicación: Alemania